氟哌啶醇对电刺激诱发伏核多巴胺释放的影响  

EFFECT OF HALOPERIDOL ON ELECTRIC STIMULATED DOPAMINE RELEASE FROM NUCLEUS ACCUMBEN

作　　者：谢俊霞[1] 唐明[1] 

机构地区：[1]青岛医学院生理学教研室

出　　处：《青岛医学院学报》1997年第2期97-99,共3页Acta Academiae Medicinae Qingdao Universitatis

基　　金：山东省自然科学基金;青年基金

摘　　要：①目的研究氟哌啶醇（ＨＡＬ）对大鼠伏核多巴胺（ＤＡ）释放的影响。②方法用快速周期伏安法，检测了小剂量（０．５ｍｇ·ｋｇ－１·ｄ－１），大剂量（１．０ｍｇ·ｋｇ－１·ｄ－１）ＨＡＬ给药组和对照组大鼠连续口服或腹腔注射ＨＡＬ前后伏核ＤＡ释放量的改变。③结果在连续２１ｄ口服０．５ｍｇ·ｋｇ－１·ｄ－１和１．０ｍｇ·ｋｇ－１·ｄ－１ＨＡＬ的大鼠，其伏核的ＤＡ释放量与对照组相比明显减少，差异有显著性（ｔ＝７．５９，２４．６６，Ｐ均＜０．００１）；腹腔注射ＨＡＬ激发后，对照组ＤＡ释放量较注射前明显增加（ｔ＝８．１５～９０．７６，Ｐ均＜０．００１）；两给药组ＤＡ释放量与注射前相比则变化较小；但与对照组相比，差异有显著性（ｔ＝３２．４１～１１５．２３，Ｐ均＜０．００１）。④结论ＨＡＬ小剂量腹腔注射可增加伏核的ＤＡ释放量，连续口服ＨＡＬ则可抑制伏核ＤＡ释放量。Objective To study the effects of haloperidol(HAL) on electric stimulated dopamine(DA) release from rat nucleus accumbens(Acb). Methods The rats was divided into low dosage(0. 5mg/kg/d) and high dosage(1.0mg/kg/d) of HAL treated groups and control group. Fast cyclic voltammetry was used to check the changes of DA release from Acb after HAL challenge. Results After continuous oral administration of high and low dosages of HAL, the DA release from Acb was significantly decreased( t=7.59; 24.66,P <0.001). After abdominal injection of HAL, the DA release from Acb in the control group was significantly increased( t=8.15￣90.76,P <0.001), while in the HAL treated groups, the changes of DA release were not obvious and the difference of DA release between the HAL treated groups and the control group was significant( t=32.41￣115.23,P< 0.001). Conclusion The results suggest that HAL challenge can increase DA release from Acb, while continuous administration of HAL can inhibit DA release.

关 键 词：氟哌啶醇 多巴胺 伏核 电刺激 DA系统 

分 类 号：R338.26[医药卫生—人体生理学]