生物降解聚乳酸中空纤维的制备及其药物体外释放的研究  

The Preparation of Poly (DL-Lactide) Hollow Fiber and the Release of Drug in Vitro

作　　者：朱家蕙[1] 沈正荣[1] 马臻[1] 吴兰亭[2] 石灯水[2] 

机构地区：[1]浙江省医学科学院药物研究所,杭州310013 [2]浙江大学高分子化学系,杭州310027

出　　处：《生物医学工程学杂志》1997年第3期247-251,共5页Journal of Biomedical Engineering

摘　　要：采用干／湿相转化法制备聚乳酸中空纤维，得到四个不同纺制体系的中空纤维，扫描电镜测定了中空纤维的膜结构和尺寸，灌药（NET）及熔封后的中空纤维的体外释药研究表明，NET的释放与中空纤维的膜壁结构有关。文章对释放机理进行初步探讨。The biodegradable hollow fibers of DL-PLA were prepared by a dry-wet phase inversion spinningprocess. By using four different spinning systems,DL-PLA hollow fibers with varying asymmetric membrane structure were obtained. The structure of hollow fiber wall was examined by SEM. In vitro release of norethisteronefrom the DL-PLA hollow fibers was also investigated. The hollow fibers were filled with a 50wiN NET in castoroil. The DL-PLA hollow fibers NET release was found to be dependant on the membrane structure of the hollowfiber wall. Possible release mechanisms were discussed.Keywoads: DL-PLA Hollow fiber Dry-wet phase inversion

关 键 词：DL-聚乳酸 中空纤维 生物降解 药物控释系统 

分 类 号：TQ464[化学工程—制药化工] O636.1[理学—高分子化学]