缓释盐酸安非他酮联合尼古丁替代治疗对烟瘾戒断临床分析  

Clinic analysis of substained-release bupropion associated with NRT for smoking cessation

作　　者：俞红霞[1] 林江涛[1] 

机构地区：[1]中日友好医院呼吸内科,北京100029

出　　处：《心肺血管病杂志》2008年第4期246-249,共4页Journal of Cardiovascular and Pulmonary Diseases

摘　　要：目的:评价缓释盐酸安非他酮联合尼古丁替代治疗对烟瘾戒断临床效果。方法:随机选择68例符合试验要求的吸烟者(平均每天吸烟约24支,Fagerstrom评分平均约7分)。随机分成2组,一组进行单纯尼古丁替代治疗(NRT)(A组),另一组进行缓释盐酸安非他酮联合尼古丁替代治疗戒烟(B组),连续观察12周戒断效果,并随访24周的戒断率。结果:治疗第4周、第12周、第24周自述戒烟率B组均高于A组(分别为48.3%,33.3%;58.6%,37.5%;48.3%,25%),2者间差异均有显著性(P<0.05)。随访期B组烟草依赖自评量表评分均小于A组(P<0.05);B组尼古丁戒断相关症状明显低于A组,且12周体质量增加明显小于A组(P<0.05);2组12周戒烟失败者以伴随哮喘及慢性阻塞性肺疾病(COPD)患者为主;戒烟失败情景诱惑分析前5位为社交、负性情绪、正性情绪、压力及饮酒等。结论:缓释盐酸安非他酮联合尼古丁替代治疗戒烟方式更有效,且戒断相关症状少,对合并慢性疾病的患者更值得推荐,戒烟过程行为心理分析治疗十分重要。Objective： To assess the effect of the abstinence from cigarettes with sustained-release bupropion combining with nicotine replacement therapy （NRT）. Method：68 cases of smoking an average of 24 cigarettes per day and exhibiting a Fagerstrom Tolerance Questionnaire （FTQ） score of 7.0, randomly divided into two groups, one group be given only NRT, another group be given by sustained-release bupropion combining with NRT. Result： Self-reported smoking withdrawal rate during 4 weeks, 12 weeks,24 weeks in sustained-release bupropion combining with NRT is higher than nicotine replacement therapy alone（48.3% ,33.3% ;58.6% ,37.5% ; 48.3% ,25% ）（ P 〈 0.05）. The score of cigrate dependence lower than later during follow-up period. （ P 〈 0. 05）. The Nicotine Withdrawal Symptoms and body weight increased is lower in sustained-release bupropion combining with NRT than in NRT alone. （ P 〈 0.05）. The situations related to relapse, in order off requency, included social contact, negative emotion, positive emotion, pressure, alchol. Conclusion： Sustained-release bupropion combining with NRT for aiding smoking reduction appeared to be safe and effective than NRT alone, specially with chronic disease. The intervention of psychological and behavior show more important.

关 键 词：缓释盐酸安非他酮缓释剂 尼古丁替代治疗 戒断率 

分 类 号：R163[医药卫生—公共卫生与预防医学]