3,5-二硝基苯甲酸酯基改性的HEMA/NVP交联微球对肌酐的吸附特性与吸附机理  

ADSORPTION OF DINITROBENZOATE-MODIFIED HEMA/NVP MICROSPHERE FOR CREATININE AND THE MECHANISM OF CHEMISORPTION

作　　者：杨莹[1] 高保娇[1] 汪剑[1] 

机构地区：[1]中北大学化学工程系,太原030051

出　　处：《高分子学报》2008年第6期587-593,共7页Acta Polymerica Sinica

基　　金：山西省自然科学基金(基金号20040402JJ)资助项目

摘　　要：制备了平均粒径为180μm的甲基丙烯酸β-羟乙酯(HEMA)与N-乙烯基吡咯烷酮(NVP)交联共聚物微球(HEMA/NVP),使用3,5-二硝基苯甲酰氯(DNBC)对其进行了化学改性,制得了表面键合有大量3,5-二硝基苯甲酸酯基(DNBZ)的功能微球DNBZ-HEMA/NVP;采用红外光谱(FTIR)与化学分析法对其化学结构及组成进行了表征;重点研究了功能微球DNBZ-HEMA/NVP对肌酐的吸附特性与吸附机理.静态吸附实验表明,DNBZ-HEMA/NVP对肌酐具有强的吸附作用,交联微球HEMA/NVP经DNBC化学改性后,对肌酐的吸附容量提高了20倍;DNBZ-HEMA/NVP对肌酐的吸附性能受介质pH值及盐度的影响很大;当pH值较小或较大时,吸附容量都较低,pH=8.5时,吸附容量最大;介质的盐度越大,吸附容量越小.研究结果表明,DNBZ-HEMA/NVP对肌酐的吸附属化学吸附,而且是静电相互作用驱动下的化学吸附.A kind of new functional polymeric microspheres with strong adsorption ability for creatinine was prepared, and the adsorption mechanism was studied in depth. First of all, the crosslinked copolymer microspheres of 2-hydroxyethyl methacrylate （HEMA） and N-vinylpyrrolidone （NVP） with an average diameter of 180 μm were prepared by suspension copolymerization and denoted as HEMA/NVP, which has biocompatibility. In the suspension copolymerization system, N,N′-methylene biscrylamide （MBA） was used as crosslinking agent, α,α′-azoisobisbutyronitrile （AIBN） was used as initiator, and Span-60 （Sorbitan monooleate） was used as suspension stabilizer. Subsequently, the microspheres HEMA/NVP were chemically modified with 3,5-dinitrobenzoyl chloride （DNBC）, and the functional microspheres DNBZ-HEMA/NVP, on which a number of 3,5-dinitrobenzoate （DNBZ） groups were bonded, were obtained. In the modification reaction, triethylamine was used as the agent to capture acid, and reaction could be carried out favourably. The chemical structure and composition of the functional microspheres were characterized with FTIR and chemical analytical method. The adsorption characteristics of DNBZ-HEMA/NVP for creatinine were studied, and the effects of various factors on the adsorption properties of the functional microspheres were investigated. Static adsorption experiments show that the functional microspheres DNBZ-HEMA/NVP have strong adsorption property for creatinine due to the chemical reaction analogous to Jaffe′ reaction between 3,5-dinitrobenzoate on the surface of the microspheres and creatinine. In the aqueous solution, creatinine has two kinds of tautomers, the keto form and the enol form. The tautomer with enol form is easy to loss a proton and produces a negative oxyanion. The negative oxyanions are attracted by the nitrogen atoms with positive electricity on the nitro groups of DNBZ. Finally, a complex reaction takes place and a complex of 1∶1σ is formed between DNBZ of the microspheres and

关 键 词：肌酐 甲基丙烯酸Β-羟乙酯 3 5-二硝基苯甲酸酯 化学吸附 静电相互作用 

分 类 号：O647.31[理学—物理化学]