鸡白细胞介素18研究进展  

Reseach Progress in Chicken Interleukin-18

作　　者：王宪文[1] 刘兴友[1] 王岩 杭柏林[1] 

机构地区：[1]河南科技学院动物科学学院,河南新乡453003 [2]郑州牧业高等专科学校,河南郑州450002

出　　处：《安徽农业科学》2008年第16期6776-6777,共2页Journal of Anhui Agricultural Sciences

摘　　要：鸡白细胞介素(IL-18)是一种新发现的细胞因子,其cDNA全长597 bp,编码198个氨基酸的前体多肽,分子量约为23 kDa,IL-18氨基端的29个氨基酸残基起胞内定位作用;鸡IL-18是IFN-γ诱生剂,通过IFN-γ发挥抗感染、促生长等作用,参与对微生物感染诱导产生细胞和体液免疫反应的初次免疫应答;鸡IL-18作为免疫佐剂,具有增强免疫和治疗作用,还具有抗肿瘤免疫作用。The chicken interleukin-18 （ChIL-18） is a newly-found cytokine,the whole gene of which has 597 base pairs,encoding a peptide of 198 amino acide with a molecular weight of 23.0 kDa, the N-terminal 29 amino acid peptide determine intracellular distribution of ChIL- 18. ChIL-18 can induce secretion of IFN-gamma which has the effection of anti-infection,promoting growth,involving in innate immune responses to microbial infection preceding the induction of both cellular and humoral immune responses. As an immune adjuvants, ChIL-18 is immunostimulator, moreover, and it can induce an effective anti-tumor immune response in chicken.

关 键 词：鸡白介素18 IFN-Γ 抗感染 

分 类 号：S858.31[农业科学—临床兽医学]