丙酮二羧酸及其衍生物的合成研究  

Synthesis of 1,3-Acetone Dicarboxylic Acid and Its Derivatives

作　　者：唐新军[1] 徐建兵[2] 臧阳陵[2] 

机构地区：[1]湖南化工职业技术学院,湖南株洲412004 [2]湖南化工研究院国家农药创制工程技术研究中心,湖南长沙410007

出　　处：《精细化工中间体》2008年第3期33-35,共3页Fine Chemical Intermediates

摘　　要：丙酮二羧酸及其衍生物是重要的医药中间体,以无水柠檬酸为原料经氧化脱羧得到丙酮二羧酸,再经酯化和硼氢化钾还原反应制备得到3-羟基戊二酸二乙酯,总收率94%,纯度98.5%。1,3-Acetone dicarboxylic acid and its derivatives were important intermediates for drug synthesis. In this paper diethyl 3-oxopentanedioate was synthesized using anhydrous citric acid as starting material, then reacted with ethanol to produce diethyl 3-oxopentanedioate. The ester product was reduced by KBH4 to afford diethyl 3- hydroxypentanedioate, the total yield was 94% and the purity was 98.5%.

关 键 词：无水柠檬酸 氯磺酸 丙酮二羧酸 还原 合成 

分 类 号：O625.56[理学—有机化学]