用MRI无损检测胆囊中的胆汁成分(英文)  

NONINVASIVE EVALUATION OF GALLBLADDER BILE COMPOSITION BY MRI

作　　者：蒲永林[1] 冯义濂[2] 叶安培[2] 王纪先 

机构地区：[1]北京医科大学,人民医院放射科北京100044 [2]北京大学电子学系,北京100871 [3]北京医科大学统计系,北京100083

出　　处：《波谱学杂志》1997年第4期331-337,共7页Chinese Journal of Magnetic Resonance

摘　　要：为了探索用磁共振成象方法无损伤检测胆囊中的胆汁成分的可能性，我们用0.5T的磁共振成象仪，对38例禁食期胆囊疾病患者（12例急性无并发症胆囊炎及胆结石，1例化浓性胆囊炎，2例急性出血性胆囊炎，14例慢性胆囊炎及胆结石，5例胆囊息肉，4例障碍性黄疸进行了轴向腹部胆囊部位T1-加权自旋-回波成象.结果表明：禁食或胆囊疾病患者胆汁中胆固醇（p＝0.014），脂肪酸（p=0.001），和铁（p＜0.001）的浓度对T1-加权成象（TR／TE＝620／25ms）的肝-胆信号强度比有明显的负影响，同时发现总蛋白质，总胆红素及Na+，K+，Cl-，Mg++离子的浓度对肝-胆MRI信号强度比无显著影响，由此可见，T1-加权MRI中的肝-胆信号强度比反映了胆囊中的胆汁成分，其中影响肝-胆信号强度比的最重要因素是胆囊中胆汁所含胆固醇、脂肪酸和铁的浓度．In order to explore the possibility of MRI in the noninvasive evaluation of gallbladder bile composition T1 - weighted spin - echo exial abdominal MR image at 0.5T and gallbladder bile compositon were obtained in 38 individuals (12 with acute uncompli-cated cholecystitis and gallbladder gallstones, 1 patient with suppurative cholecystitis, 2 with acute hemorrhagic cholecystitis, 14 with chronic cholecystitis and gallbladder stones, 5 with gallbladder polyps, 4 with obstructive jaundice) in fast stage. The results show that the concentrations of cholesterol (p = 0.014), fatty acids (p = 0.001) and iron (1, < 0.001) in the gallbladder bile in fast stage were significantly and negatively associated with liver- gallblad-der signal intensity ratio on the T1 weighted image (TR/TE = 620/25 ms). No significant association was found betweell the liver - gallbladder signal intensity ratio and the concen-trations of total protein, total bilirubin, Na+, K+, Cl- and Mg++. We conclude that the liver- gallbladder signal intensity ratio on the T1- weighted RM image can reflect gallbladder bile composition. The strongest determinants of the liver - gallbladder signal intensity ratio are the concentrations of cholesterol, fatty acids and iron.

关 键 词：核磁共振 医学磁共振成象 胆囊 胆汁分析 

分 类 号：R446.19[医药卫生—诊断学] R445.2[医药卫生—临床医学]