^(99)Tc^mN-MIBI 的制备及其生物分布研究  

THE PREPARATION AND BIODISTRIBUTION OF A NEW 99 Tc m NITRIDO COMPLEX 99 Tc mN MIBI

作　　者：张现忠[1] 王学斌[1] 张俊波[1] 

机构地区：[1]北京师范大学化学系

出　　处：《同位素》1997年第3期158-162,共5页Journal of Isotopes

摘　　要：为获得新型心肌显像剂，以ＳｎＣｌ２·２Ｈ２Ｏ为还原剂制备了［９９Ｔｃｍ≡Ｎ］２＋中间体，然后由配体交换反应得到标记率＞９０％的９９ＴｃｍＮ－ＭＩＢＩ配合物，并优化了配体交换反应条件。９９ＴｃｍＮ－ＭＩＢＩ在制备后室温放置１０ｈ放化纯度仍＞９０％，分配系数Ｐ＝３３．７０。小鼠体内生物分布结果显示：９９ＴｃｍＮ－ＭＩＢＩ具有较高的早期心肌摄取，清除较快，在注射后５ｍｉｎ时心／血、心／肺、心／肝比分别为３．１８、１．７２和１．４２。其与９９Ｔｃｍ－ＭＩＢＩ的生物分布有显著不同。The technetium 99m nitrido intermediate is synthesized by using SnCl 2·2H 2O as reductant, and the complex 99 Tc mN MIBI is obtained through ligand exchange reaction. The labelling yield of 99 Tc mN MIBI is over 95% by TLC. The conditions of preparing 99 Tc mN MIBI are optimized. Results of stability and partition coefficient of 99 Tc mN MIBI indicate that the complex is lipophilic and stable over 10 h at room temperature. The biodistribution of 99 Tc mN MIBI in mice shows high myocardium uptake, and rather rapid clearance. For 5 min post injection the heart to blood, heart to lung and heart to liver ratios are 3.18, 1.72 and 1.42, respectively. The new complex may be suitable for instant myocardial imaging. 99 Tc mN MIBI has significant different biodistribution characteristics from 99 Tc m MIBI. Based on these promising properties, 99 Tc mN MIBI should be a new potential myocardial perfusion imaging agent.

关 键 词：锝99 MIBI 心肌灌注 显像剂 生物分布 

分 类 号：R817.42[医药卫生—影像医学与核医学]