精神活性物质对组蛋白乙酰化修饰的影响  

The Influence of Psychoactive Substance on Histone Acetylation Modification

作　　者：景丽[1] 梁建辉[1] 

机构地区：[1]北京大学中国药物依赖性研究所,北京100083

出　　处：《生理科学进展》2008年第3期221-224,共4页Progress in Physiological Sciences

基　　金：国家重点基础研究发展计划(973计划)(2003CB515400);国家自然科学基金(30570653);教育部985项目(北京大学天然药物及仿生药物国家重点实验室)资助课题

摘　　要：当前,精神活性物质的滥用和成瘾呈上升趋势,其既是一个严重的社会问题,又是一个非常重要的医学问题。表观遗传学的研究发现,基因表观事件的发生与精神活性物质的滥用和成瘾有着密切的关系,其中组蛋白乙酰化修饰起了关键作用。本文着重阐述了可卡因、苯丙胺、甲基苯丙胺、吗啡和酒精等多种精神活性物质对组蛋白乙酰化的影响。Psychoactive substance abuse and addiction have increasingly become severe, which are not only a serious social problem, but an important medical problem as well. Recent studies have demonstrated that the histone acetylation modification is an important epigenetic mechanism of gene regulations and plays essential roles in psychoactive substance abuse and addiction. The present review mainly presents the influence of several psychoactive substances, including cocaine, amphetamine, methamphetamine, morphine, and alcohol, on histone acetylation modification.

关 键 词：精神活性物质 组蛋白乙酰化修饰 成瘾记忆 行为敏化 

分 类 号：R971[医药卫生—药品]