斯钙素的研究进展  

Progress in the Research of Stanniocalcin

作　　者：陈维娜[1] 朱广瑾[1] 

机构地区：[1]中国医学科学院中国协和医科大学基础医学研究所病理生理学系,北京100005

出　　处：《生理科学进展》2008年第3期225-228,共4页Progress in Physiological Sciences

摘　　要：斯钙素(stanniocalcin,STC)是一种糖蛋白激素,最早在硬骨鱼中发现,起着调节钙/磷平衡的作用。近年来在人和其它哺乳动物中发现也存在STC,先后分别命名为STC1和STC2。STC1基因可以产生两种形式的STC:一个是分子量为50kD的多肽,被称作STC50;另一种是一组分子量较大的不同形式的STC,被统称为big STC。STC1和STC2均可广泛表达于各种组织。STC成为一种新的肿瘤标志物,并且在心血管疾病、炎症细胞迁移、胚泡着床和子宫的蜕膜化等多方面都起重要作用。Stanniocalcin （STC） is a glycoprotein hormone first identified in bony fish in which it regulates calcium and phosphate homeostasis. Stanniocalcin is also identified in human and mammals and is named STCland STC2 by the sequence of finding. There are two forms of STC produced by the STC1 gene; a 50kD polypeptide known as STC50 and a group of higher molecular weight variants that are collectively referred to as big STC. Both STC1 and STC2 are widely expressed in various tissues. STC is identified as a novel marker for human cancer and plays an important role in heart disease, transendothelial migration of inflammatory cells, embryo implantation and decidualization.

关 键 词：斯钙素 肿瘤 缺氧预处理 胚泡着床 线粒体 

分 类 号：Q291[生物学—细胞生物学]