小剂量高渗高胶液体对失血性休克兔复苏效果的实验观察  

The Observation of the Effect of Small Dose of HOME Hypertonic Sodium Chloride and Hydroxyethyl Starch on Resuscitation of Hemorrhagic Shock Rabbits

作　　者：杨美菊 刘洋 朱红军[2] 

机构地区：[1]商丘高等医学专科学校,河南省商丘市476100 [2]商丘市第一人民医院心胸外科

出　　处：《医学理论与实践》2008年第7期748-750,共3页The Journal of Medical Theory and Practice

摘　　要：目的:研究HOME注射液(高渗氯化钠羟乙基淀粉40溶液,HH40)复苏失血性休克兔对其平均动脉压、电解质和血气影响。方法:新西兰白兔36只随机等分为3组:HH40组、HTS(7.5%高渗氯化钠溶液)组、LRS(林格液)组。采用Wigger’s改良法制作失血性休克模型,休克60min后分别用5mg/kg的HH40、HTS、LRS复苏。于放血前、输液前、输液后10min、60min、180min分别记录平均动脉压(MAP),检测其动脉血的血气分析、电解质值。结果:HH40和HTS可以使休克兔的MAP升高,并维持时间较长;动脉血氧分压(PaO2)有所回升,动脉血pH、血液碱剩余(BE)、标准碳酸氢盐(SB)等指标下降趋势减慢,且给药后血Na+升高不明显。结论:HOME注射液是抢救失血性休克有效的新药。ObJective： To investigate the effects of hypertonic sodium chloride hydroxyethyl starch 40（HH40） on MAP,electrolYte and arterial blood gas in hemorrhagic shock rabbits. Methods.. Thirty-six rabbits of both sexes weighing 2. 5-3.0kg were randomly divided into 3 groups： HH40 group （n= 12）, hypertonic saline group（HTS group, n = 12） and lactated Ringer＇s solution group （LRS group, n= 12）. The animals were anesthetized with 3 % pelltobarbitalum Natricum 30mg/kg. Hemorrhagic shock was induced according to Wigger＇ s. MAP was maintained at 45mmHg for 60min. Then the animals in three groups were resuscitated respectively with HH40 5ml/kg, HLS 5ml/kg and 5ml/kg LRS. MAP, electrolyte and arterial blood gas were measured before shock （baseline）, during shock before resuscitation, and at several points after fluid resuscitation. Results：After resuscitation in HH40-treated group the MAP , electrolyte and arterial blood gas were significantly different compared with those in HTS-treated group or in LRS-treated group. Conclusion. HH40 is a safe and effective anti-shock drug.

关 键 词：高渗氯化钠 羟乙基淀粉 失血性休克 平均动脉压 电解质 血气分析 

分 类 号：R605.971[医药卫生—急诊医学]