麻风病患者治愈后肿瘤坏死因子α的研究  

Study of Tumor Necrosis Factor α in Cured Leprosy Patients

作　　者：高锦程[1] 虞海燕[1] 郑碧忠[1,2] 方海林[3] 李敏伟[3] 

机构地区：[1]浙江医科大学附属邵逸夫医院皮肤科 [2]兰溪市皮肤病防治站 [3]浙江医科大学传染病研究所分子免疫室

出　　处：《中华皮肤科杂志》1997年第5期321-323,共3页Chinese Journal of Dermatology

摘　　要：为了解麻风病患者治愈后免疫功能状况，研究肿瘤坏死因子α（ＴＮＦα）在麻风病免疫反应中的潜在作用和调节异常，进一步探讨麻风病抗感染免疫发病机理，对浙江省兰溪地区各型麻风病治愈者６２例（其中ＢＢ～ＬＬ型和ＴＴ～ＢＴ型麻风病治愈者各３３例和２９例）及其直系亲属２８例的血清ＴＮＦα进行检测，以当地正常人作对照。检测结果各型麻风病治愈者血清ＴＮＦα水平均明显低于正常人对照组（Ｐ值＜０．０２～０．０１），以瘤型（ＬＬ）麻风治愈者降低最显著，而ＢＢ～ＬＬ与ＴＴ～ＢＴ麻风病治愈者、麻风病患者直系亲属与正常人对照组之间ＴＮＦα均无显著性差异（Ｐ值均＞０．０５）。提示麻风病患者治愈多年仍存在ＴＮＦα调节紊乱及免疫功能低下，ＴＮＦα水平的低下与麻风病患者对麻风杆菌特异性细胞免疫缺陷的发病机理有关。In order to understand the immunofunction in cured patients with leprosy, and study the immunopathogenetic role of TNF α in leprosy patients and anti infection immuno mechanism of TNF α in leprosy patients, serum levels of TNF α of 62 cured leprosy patients and 28 their first generation relatives in Lanxi County, Zhejiang Province were determined, and local normal persons were randomly selected as controls.The results showed that the TNF α of different types of cured leprosy patients were lower than those of normal controls(P<0 02～0 001). The TNF α levels of lepromatous leprosy patients were the lowest among all patients.But the TNF α levels between BB LL patients and TT BT patients, and the TNF α levels between leprosy patient relatives and normal controls showed no significant difference(P>0 05).The results of this paper suggest that the cured patients still have TNF α disturbance and decreased immunofunction, and decreased level of TNF α may relate to the specific immuno deficiency of leprosy patients to M.leprae. It also suggests that the TNF α level of cured leprosy patients does not correlate with the type and prognosis of leprosy patients.

关 键 词：麻风病 肿瘤坏死因子Α 治疗 

分 类 号：R755.03[医药卫生—皮肤病学与性病学]