活性纳米羟基磷灰石复合胶原／聚乳酸材料应用于牙槽嵴扩增的研究  

Animal Model to assess Lateral Augmentation of Mandible.

作　　者：陈鹏[1] 刘冰[2] 毛天球[3] 

机构地区：[1]中国人民解放军总医院口腔颌面外科,北京100853 [2]中国人民解放军空军总医院口腔科 [3]中国人民解放军第四军医大学口腔医院口腔颌面外科

出　　处：《口腔医学研究》2008年第3期282-284,共3页Journal of Oral Science Research

摘　　要：目的:构建下颌牙槽嵴扩增的动物模型,并初步观察nHAC/PLA复合rhBMP-2在下颌皮质骨表面贴附式植骨的成骨能力。方法:制备AnHAC/PLA材料,将HAC/PLA、AnHAC/PLA材料分别植入新西兰兔下颌骨颊侧皮质骨表面,设计皮质骨颊侧制备沟槽的改良术式组,并与无沟槽的普通术式组对比,术后8周通过大体、X线、组织学观察来研究其牙槽骨加宽的能力。结果:AnHAC/PLA材料较nHAC/PLA材料更能良好的增加下颌骨的宽度,在皮质骨表面增加刻槽的改良术式能明显增加材料的成骨情况。结论:AnHAC/PLA材料可以有效地增加牙槽骨宽度。Objective： To explore the rabbit model and of bone augmentation to evaluate bone formation with AnHAC/PLA. Methods： AnHAC/PLA was mixed by nHAC/PLA with rhBMP-2. AnHAC/PLA or nHAC/PLA were implanted on mandibule of rabbits, the other side was control. The morphological and histological measurement were carried out 8 weeks after operation. Results： The graft was covered with new bone. Mandibule width was widened by nHAC/PLA and AnHAC/ PLA. The mandibule was wider in AnHAC/PLA group than nHAC/PLA group. There were more new bone in the improved operation group. Conclusion： The model could be used as animal experimental model to assess lateral augmentation substitutes.

关 键 词：纳米羟基磷灰石复合胶原/聚乳酸材料 活性纳米羟基磷灰石复合胶原/聚乳酸材料 重组人骨形成蛋白-2 牙槽嵴 

分 类 号：R318.08[医药卫生—生物医学工程]