肺炎和腹泻患儿亚临床维生素A缺乏的研究  

A study on preclinical vitamin A deficiency in children with pneumonia or diarrhea

作　　者：谈藏文[1] 吴光驰[1] 周新宇[1] 孙吉萍[1] 潘红[1] 王树山[1] 聂明[1] 邓莉[1] 

机构地区：[1]首都儿科研究所

出　　处：《中华儿科杂志》1997年第11期563-566,共4页Chinese Journal of Pediatrics

摘　　要：为探讨肺炎和腹泻患儿体内维生素Ａ（ＶＡ）状况及其与疾病的关系，对１２８例肺炎、１１６例腹泻患儿和１００名健康儿童测定血清ＶＡ，其均值分别为１．１±０．５μｍｏｌ／Ｌ，０．８±０．４μｍｏｌ／Ｌ和１．９±０．６μｍｏｌ／Ｌ（Ｆ＝１４６．６７０，Ｐ＜０．０１）。对其中６０例肺炎、８５例腹泻患儿进行ＶＡ的相对剂量反应（ＲＤＲ）测定，其ＲＤＲ均值分别为２２％±１９％，２３％±１０％，亚临床ＶＡ缺乏（ＰＶＡＤ）检出率分别为４３．３％，６１．２％。发病１，２～４，５～７天即入院的肺炎、腹泻患儿在入院次日所测的ＲＤＲ均值和ＰＶＡＤ检出率均相近（肺炎患儿的Ｈｃ＝２．５６０，χ２＝０．２６２，Ｐ均＞０．０５；腹泻患儿的Ｈｃ＝０．２２９，χ２＝０．５１０，Ｐ均＞０．０５）。在诊断肺炎、腹泻患儿ＰＶＡＤ时，均以ＲＤＲ法检出率为高。提示：肺炎、腹泻患儿血清ＶＡ水平低于健康儿童，约半数的患儿体内处于ＰＶＡＤ状态。在发病７天内体内ＶＡ水平不受病程影响。评价体内ＶＡ状况以ＲＤＲ法更为敏感可靠。To explore body vitamin A (V A) status of children with pneumonia or diarrhea and the relationship between V A status and the diseases, the authors measured serum V A of 128 pneumonia cases, 116 diarrhea cases and 100 healthy children with the trace fluorescence method and performed relative dose response (RDR) analysis in the sick children. The result showed that serum V A levels of the cases with pneumonia, diarrhea and healthy children were 1.1±0.5 μmol/L, 0.8±0.4 μmol/L and 1.9±0.6 μmol/L, respectively ( F =146.670, P <0.01). The incidences of preclinical V A deficiency (PVAD) were 20.3%, 45.7% and 1.0%, respectively (χ 2=61.092, P <0.01). RDR average values of children with pneumonia or diarrhea were 22%±19% and 23%±10%, respectively. Their incidences of PVAD were 43.3% and 61.2% respectively. RDR means and occurrence of PVAD of children who were admitted to the hospital 1, 2～4, 5～7 days after the onset of the diseases were all similar when tested at the day after hospitalization ( H c=2.560, H c=0.229, χ 2=0.262, χ 2=0.510, P > 0.05). These data suggested that serum V A levels of children with pneumonia or diarrhea were clearly lower than those of the healthy children. About half of the children with pneumonia or diarrhea were in PVAD status, which might have existed before they actually became ill. RDR seems to be sensitive and reliable for evaluting body V A status.

关 键 词：维生素A缺乏 肺炎 腹泻 

分 类 号：R563.102[医药卫生—呼吸系统] R591.410.2[医药卫生—内科学]