单纯性肥胖儿童高脂血症与脂肪肝的关系  

A study on the relation of simple obesity in children with hyperlipidemia and fatty liver

作　　者：万燕萍[1,2,3] 胡冰[1,2,3] 蔡威[1,2,3] 曹兰芳 汤庆娅[1,2,3] 于黎华 濮宗伟 

机构地区：[1]上海第二医科大学附属仁济医院儿科 [2]上海第二医科大学新华医院临床营养中心 [3]华东师范大学统计系

出　　处：《中华儿科杂志》1997年第11期577-579,共3页Chinese Journal of Pediatrics

基　　金：上海青年科技启明星资助

摘　　要：为探讨单纯性肥胖儿童伴高脂血症与脂肪肝之间的关系，对４０例肥胖儿（平均年龄９岁）与２３名正常体重儿（平均年龄８．６岁）的血脂和肝功能各项指标进行了比较；并对３０例肥胖儿做了肝脏－Ｂ型超声检查。结果显示，肥胖组血总胆固醇（Ｔ－ｃｈ）、低密度脂蛋白（ＬＤＬ）、载脂蛋白Ｂ１００（Ａｐｏ－Ｂ１００）、丙氨酸转氨酶（ＡＬＴ）、天冬氨酸转氨酶（ＡＳＴ）和碱性磷酸酶（ＡＫＰ）均明显高于正常对照组（Ｐ＜０．０５或Ｐ＜０．０１）；肝脏Ｂ超结果显示１５例异常，９例轻度脂肪肝，６例脂肪肝。提示单纯性肥胖儿伴高脂血症者脂肪肝较常见，为预防脂肪肝发生，应早期治疗儿童肥胖症。To evaluate the relationship between simple obesity and hyperlipidemia and fatty liver in children, the authors measured fasting blood total choleslerol (Tch), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), apolipoprotein A1 (Apo A1), apolipoprotein B100 (Apo B100), serum alanine transaminase (ALT) and aspartate transaminase (AST) in 40 obese children and 23 normal children as a control group. The authors also performed ultrasound examination for the liver in 30 obese children. The results showed that the levels of Tch, TG, LDL, Apo B100 in obese group, were significantly higher than those in control group, the values of ALT and AST in obese group were higher than those in control group, but less than adult normal values. The ultrasound examination showed fatty liver in 15 obese children and their alkaline phosphatase value was significantly higher than that of the control group. The authors concluded that simple obese children with hyperlipidemia were colsely related to occurrence of fatty liver.

关 键 词：肥胖症 高脂血症 脂肪肝 儿童 

分 类 号：R589.202[医药卫生—内分泌] R575.502[医药卫生—内科学]