Preparation and bioactivity of sol-gel macroporous bioactive glass  

作　　者：Zhihua Zhou Jianming Ruan Jianpeng Zou Zhongcheng Zhou 

机构地区：[1]State Key Laboratory for Powder Metallurgy, Central South University, Changsha 410083, China [2]College of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan 411201, China

出　　处：《Journal of University of Science and Technology Beijing》2008年第3期290-296,共7页北京科技大学学报（英文版）

基　　金：the National Natural Science Foundation of China(No.50174059)

摘　　要：Bioactive glass is well known for its ability of bone regeneration, and sol-gel bioactive glass has many advantages compared with melt-derived bioactive glass. 3-D scaffold prepared by the sol-gel method is a promising substrate material for bone tissue engineering and large-scale bone repair. Porous sol-gel glass in the CaO-SiO2-P205 system with macropores larger than 100 μm was prepared by the addition of stearic acid as a pore former. The diameter of the pore created by the pore former varied from 100 to 300 μm. The formation of a hydroxyapatite layer on the glass was analyzed by studying the surface of the porous glass by scanning electron microscopy, energy dispersive spectroscopy, X-ray diffraction, and Raman spectra after they had been immersed in simulated body fluid （SBF） for some time, and the porous glass shows good bioactivity.Bioactive glass is well known for its ability of bone regeneration, and sol-gel bioactive glass has many advantages compared with melt-derived bioactive glass. 3-D scaffold prepared by the sol-gel method is a promising substrate material for bone tissue engineering and large-scale bone repair. Porous sol-gel glass in the CaO-SiO2-P205 system with macropores larger than 100 μm was prepared by the addition of stearic acid as a pore former. The diameter of the pore created by the pore former varied from 100 to 300 μm. The formation of a hydroxyapatite layer on the glass was analyzed by studying the surface of the porous glass by scanning electron microscopy, energy dispersive spectroscopy, X-ray diffraction, and Raman spectra after they had been immersed in simulated body fluid （SBF） for some time, and the porous glass shows good bioactivity.

关 键 词：macroporous glass SOL-GEL in vitro bioactivity bone repair 

分 类 号：TB39[一般工业技术—材料科学与工程]