细胞间黏附分子-1基因多态性与心绞痛关系  

Study on relationship between K/E gene polymorphism and angina

作　　者：温培娥[1] 路方红[1] 周伟[1] 商青[1] 王舒健[1] 徐凤华[1] 

机构地区：[1]山东省医学科学院基础医学研究所,济南250062

出　　处：《中国公共卫生》2008年第7期808-809,共2页Chinese Journal of Public Health

基　　金：山东省自然科学基金资助项目(Y2005C39)

摘　　要：目的探讨细胞间黏附分子-1(ICAM-1)基因K469E与心绞痛的关系。方法采用候选基因法及病例-对照的方法,利用巢式PCR(nested-PCR)技术,对71例心绞痛和164例对照,进行ICAM-1基因K469E多态性分析。结果病例与对照2组间年龄、性别、体质指数、是否吸烟,收缩压、舒张压、总胆固醇、甘油三酯和高密度脂蛋白等差异均无统计学意义;ICAM-1基因K469E基因型KK在心绞痛组为28例,占39.4%;KE为30例,占42.3%,EE为13例,占18.3%;K等位基因与心绞痛相关,含有KK或KE基因型的人患心绞痛危险性是EE型的2.525倍。结论ICAM-1基因K469E多态性与心绞痛发生有关,可能是冠心病(心绞痛)潜在的独立危险因素。Objective To detect the relationship between K/E gene polymorphism and angina in Chinese population. Methods In the casecontrol study, we enrolled 71 patients with angina and 164 controls. All patients and controls were genotyped by polymerase chain reaction and allele - specific oligonucleotide techniques for the ICAM - 1 polymorphism. Resuits Conventional cardiovascular risk factors including age, sex, BMI, smoke, blood pressure and blood lipid showed no significant difference between case and control group （P 〉0.05）. The distribution of genotype （KK, KE, EE ） in angina and control groups was 28 （39.4 % ）, 30 （42.3 % ）, 13 （ 18.3 % ） and 40 （24.4 % ）, 65 （39.6 % ）, 59 （36.0 % ）, respectively. K allele gene correlated with angina and people with KK or KE genotypes had 2. 525 times high risk of angina than those with EE genotype. Conclusion There is relationship between the K469E polymorphism of ICAM - 1 gene and angina, which may be a potential factor influencing the risk of coronary heart disease （angina）.

关 键 词：细胞间黏附分子-1 基因多态性 心绞痛 

分 类 号：Q754[生物学—分子生物学]