富硒竹节人参提取物降血脂及抗氧化作用  

Effects of high-selenium panax japonicus extracts on reducing blood lipid and antioxdation

作　　者：艾明仙[1] 刘红[1] 陈龙全[1] 

机构地区：[1]湖北民族学院医学院药理教研室,恩施445000

出　　处：《中国公共卫生》2008年第7期849-850,共2页Chinese Journal of Public Health

基　　金：湖北省自然科学基金项目(2003ABAl58)

摘　　要：目的观察富硒竹节人参提取物对实验性高脂血症大鼠血脂及抗氧化作用的影响。方法采用高脂饲料喂养大鼠建立高脂血症模型,富硒竹节人参提取物按2,4g/(kg.bw)给大鼠灌胃,1次/d,连续4周。4周后取血测定血脂及抗氧化酶含量。结果富硒竹节人参提取物高、低剂量组可降低大鼠血清总胆固醇(TC)和甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)的含量,升高高密度脂蛋白胆固醇(HDL-C),高剂量组作用尤其明显;可使血清总抗氧化能力(T-AOC)、超氧化物歧化酶(SOD)及谷胱甘肽过氧化物酶(GSH-Px)活力上升,丙二醛((MDA)含量降低,与高脂模型组比较差异有统计学意义(P<0.05或P<0.01)。结论富硒竹节人参提取物能降低高脂饲料喂养大鼠的血脂水平,提高抗氧化能力,抑制脂质过氧化。Objective To study the effects of high selenium panaxjaponicus extracts on serum lipids and antioxidative enzyme in hyperlipidemic rats. Methods The hyperlipidemic model was established by feeding rats with high - fat diet. After 4 weeks the serum lipids and antioxidative enzymes content were determined respectively. Results Compared with the model, high - selenium panax japonicus extracts lowered the serum total cholesterol （TC）, triglyceride （TG）, low density lipoprotein cholesterol（LDL- c）malondialdehyde（MDA）, increased high density lipoprotein cholesterol（ HDL - c）, total antioxidative capacity（T - AOC）, superoxide dismutase （SOD） and glutathioneperoxidaes（ GSH - Px） activities significantly（ P 〈 0.05or P 〈 0.01）. Conclusion High - selenium panax japonicus extracts can lower the serum lipid level, enhance the antioxidation and inhibit the lipid peroxidation in the rats with hyperlipidemia.

关 键 词：富硒竹节人参 高脂血症 血脂 抗氧化 

分 类 号：R285.5[医药卫生—中药学] R151.3[医药卫生—中医学]