吗啡注射对大鼠自伤行为的影响  

Effect of morphine injection on serf-injurious behavior in rats

作　　者：冯坤[1] 高玉峰[1] 罗庆华[1] 社莲[1] 蒙华庆[1] 周文华[2] 张富强[2] 唐甩恩[2] 

机构地区：[1]重庆医科大学附属第一医院心理卫生中心,重庆400016 [2]宁波微循环与莨菪类药研究所

出　　处：《中国行为医学科学》2008年第7期584-587,共4页Chinese Journal of Behavioral Medical Science

基　　金：国家自然科学基金资助项目（30570658）;重庆市自然科学基金科研项目（03-2-105）

摘　　要：目的观察吗啡注射对大鼠自伤行为（self-injurious behavior，SIB）的影响及不同给药模式之间自伤行为的差别。方法将SD（Sprague—Dawley）大鼠随机分为生理盐水对照组，吗啡自身给药组，yoked-吗啡对照组。通过鼻触反应建立由灯光线索诱导的静脉自身给药模型，同时记录自身给药训练期间（每次剂量1mg／kg，每日限量50次，14d，每天4h）各组的自残程度及自残率的变化。结果首先建立了稳定的灯光线索诱导的吗啡自身给药模型，有效鼻触反应数（35±4）次，其次自训练第10天起，自身给药组及yoked-吗啡组自伤行为的发生率均达到100％，92％的大鼠为前掌及后掌的断裂咬伤，但2组自伤程度比较差异无显著性（P〉0．05）。结论吗啡注射能够导致SD大鼠产生严重的自伤行为，自伤率随着训练的进行而升高，自伤行为的产生与精神活性物质的药理作用密切相关，而与精神活性物质所引起的觅药行为关系不大。Objective To observe the effect of morphine injection on self-injurious behavior in rats. Methods SD rats were tested randomly in saline controls group, yoked-morphine controls group and morphine self-administration group. Male SD rats were trained by nose-poke response to self-administer morphine （ 1 mg/kg, i. v. ,perinfusion,limit 50 infusions per day for 14 days of 4-hour training sessions daily）. To record the extent and rate of self-injurious behavior in each group. Results Stable morphine self-administration behavior which induced by light cues was successfully established ,with （35±4） active nose-poke responses per session. From the 10th day ratio of self-injurious behavior had reached 100% in yoked-morphine controls group and morphine self-administration group,92% rats injured by biting foots. But there had no significant difference in the degree of self-injurious between two groups by wilcoxon statistics methods （ P 〈 0.05）. Conclusion Severe self-injur/ous behavior of rats could be induced by morphine injection model, it＇ s style was similar with the classic model and the rate of self-injurious behavior increased during the training. This behavior might be related to the pharmacological effects of psychoactive substances, but not the rewarding effect,specific mechanisms needs further study.

关 键 词：自伤行为 吗啡 自身给药 动物模型 

分 类 号：R96[医药卫生—药理学]