静息态下正常人脑局部一致性的性别差异  

Gender differences in regional homogeneity in healthy individuals：a resting-state fMRI study

作　　者：王丽[1] 姚志剑[1,3] 卢青[2] 刘海燕[1] 曹燕翔[1] 滕皋军[3] 

机构地区：[1]南京医科大学脑科医院精神科,南京210029 [2]东南大学学习科学研究中心 [3]东南大学附属中大医院放射科

出　　处：《中国行为医学科学》2008年第7期603-605,共3页Chinese Journal of Behavioral Medical Science

基　　金：国家自然科学基金资助项目（30500179）;江苏省自然科学基金资助项目（BK2005427）;南京市医学重点科技发展项目（IKX05003）

摘　　要：目的将功能磁共振成像（fMRI）用于正常人静息态研究，以探讨正常人静息态下脑局部一致性的性别差异。方法15例男性健康者与15例年龄、受教育程度均相匹配的女性健康者参加静息态fMRI扫描。利用局部一致性（regional homogeneity，ReHo）方法分析fMRI数据，SPM2软件进行双样本t检验，设对比有差异（P〈0．005，未校正）的体素范围（k值）≥10为差异具有显著性。结果较女性健康组，男性健康组右额上回、左颞下回、左中央前回、左侧语言中枢、左丘脑与左海马旁回ReHo值更高（P〈0．005，k值≥10）；较男性健康组，女性健康组右额中回、左角回、左丘脑枕与双侧丘脑中背侧核ReHo值更高（P〈0．005，k值≥10）。结论静息态下正常人的脑神经活动存在性别差异。Objective To explore the gender differences of brain regional homogeneity（ReHo） in healthy individuals during resting-state using fMRI. Methods 15 male healthy individuals and 15 female healthy individuals experienced the resting-state fMRI scans. ReHo approach was used to analyse the imaging data,SPM2 was used to perform two-sample t -test, voxels with a P value 〈 0. 005 （uncorrected） and cluster size （ k value） ≥ 10 voxels were used to determine statistical significance. Results Compared with women healthy group, men healthy group showed significantly increased ReHo in right superior frontal gyrus,left inferior temporal gyrus,left precentral gyrus ,left lingual gyrus, left thalamus and left parahippocampal gyrus （ P.〈 0. 005 and k ≥ 10）. Compared with men healthy group, women healthy group showed significantly increased ReHo in right middle frontal gyrus,left angular gyrus,left pulvinar and bilateral medial dorsal thalamus （ P 〈 0. 005 and k ≥ 10 ）. Conclusion The results indicated that there are gender differences in the brain activity of healthy individuals in resting state.

关 键 词：性别差异 功能磁共振成像 静息态 局部一致性 

分 类 号：R338[医药卫生—人体生理学]