体外循环心内直视手术病人血中内源性洋地黄样物质变化的临床研究  

Clinical Study on Changes of Serum Endogenous Digitalis-Like Substances (EDLS) in Open-heart Surgery under Cardiopulmonary Bypass (CPB).

作　　者：芮军[1] 方冰[1] 黎新建[1] 张力[1] 张志国[1] 仇滔[1] 袁武[1] 罗勇[1] 

机构地区：[1]四川省成都市第三人民医院胸心外科,四川成都610031

出　　处：《四川省卫生管理干部学院学报》2008年第1期8-10,共3页Journal of Sichuan Continuing Education College of Medical Sciences

摘　　要：目的:探讨体外循环手术病人血中内源性洋地黄样物质含量及其影响。方法:测定29例体外循环手术过程中病人血中内源性洋地黄样物质(EDLS)和血钠含量,11例非体外循环手术病人手术前后EDLS水平作为对照,分析不同病情及不同手术方式患者血中EDLS的变化。结果:体外循环手术病人术前血中EDLS含量明显高于对照组(P<0.05);体外循环手术后EDLS增高,术后2小时达峰值(P<0.01),后逐渐下降;血钠含量在术后2小时和术后1天明显低于术前(P<0.05)。结论:体外循环手术病人血中EDLS一过性升高,此时血中EDLS值与血钠含量降低无关。Objective：To Study the changes of serum endogenous digitalis-Like substances in open-heart surgery under cardiopulmonary bypass. Methods： Serial serum EDLS levels and serum Na ＋ value were measured in 29 cases of open-heart operations under CPB and 11 eases of noncardiac operations as control group. Results：EDLS rose up gradually after bypass, reaching it＇s peak value at 2 hour after operations （ P 〈 0. 01 ）. Serum Na ＋ value decreased significantly in 2 hour and the first day after operation （ P 〈 0. 05 ）. The peak value of EDLS were uncorrelated with the serum Na＋ value in 2 hour after operations （ P 〉 0.05）. Conclusions：The temporarily increased serum EDLS in open-heart operation under CPB is uncorrelated with the serum Na ＋ .

关 键 词：体外循环 内源性洋地黄样物质 血钠 

分 类 号：R654[医药卫生—外科学]