外周血CD_5^+ B细胞与HBV感染慢性化、严重化的关系  

Relation between CD_5^+ B cells in peripheral blood and the chronic and severe process of hepatitis B

作　　者：陈士俊[1] 陈文娟[2] 徐可树[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院 [2]山东大学医学院

出　　处：《山东医药》2008年第16期18-20,共3页Shandong Medical Journal

摘　　要：目的探讨CD5+B细胞是否参与乙型肝炎的慢性化及严重化进程。方法将慢性肝病患者分为慢性乙型肝炎、慢性重型肝炎、肝炎后肝硬化三组,并设健康对照。检测肝脏各项检测指标(丙氨酸转移酶、天冬氨酸转移酶、总胆红素、间接胆红素、碱性磷酸酶、γ-谷氨酰转肽酶、白蛋白、球蛋白、凝血酶原活动度、胆固醇及HBV-DNA定量),应用流式细胞仪检测外周血CD5+B细胞百分率。结果肝硬化组CD5+B细胞百分率明显高于对照组;慢性乙肝组CD5+B细胞百分率与凝血酶原活动度有相关性(r=0.457,P<0.05),与肝功能其他各项指标均无相关性;其余各组与肝功能各项指标均无相关。结论CD5+B细胞可能参与了乙型肝炎慢性化进程,但与病情严重程度无关。Objective To investigate whether CD5^＋ B cells participated in the chronic and severe progress of hepatitis B. Methods Chronic hepatitis patients were divided into three groups （ chronic hepatitis B,sever chronic hepatitis B and hepatic cirrhosis） ,15 out-patient clinic healthy volunteers were taken as control group. Liver indexs （ALT,AST,TB,TD, ALP, γ-GT, A, G, PTA, CHO, HBV-DNA） were detected and the rate of CD5^＋ B ceils was detected by flow eytometry. Results The rates of CD5^＋ B ceils of hepatic cirrhosis group were obviously higher than that of control group; the rate of CD5^＋ B cells of chronic hepatitis B patients has positive relation with PTA, but there was no relation with other liver function ; in sever chronic hepatitis B and hepatic cirrhosis patients,there was no relation with every liver index. Conclusions CD5^＋ B ceils may participate in the chronic process of hepatitis B, but have no relation with the severe progess of hepatitis B.

关 键 词：CD5^+B细胞 肝炎 乙型 流式细胞术 肝功能试验 

分 类 号：R512.6[医药卫生—内科学]