还原型谷胱甘肽在梗阻性黄疸手术患者术后肝功能保护中的作用  

Protection of reduced glutathione for liver function in postoperative patients with obstructive jaundice

作　　者：李勇[1] 张培建[1] 郎洁[1] 

机构地区：[1]扬州大学第二临床医学院普外科研究室,扬州225001

出　　处：《药品评价》2008年第7期306-307,314,共3页Drug Evaluation

摘　　要：目的观察还原型谷胱甘肽(阿拓莫兰)在梗阻性黄疸手术患者术后肝功能的保护作用及治疗效果。方法采用随机平行对照试验设计,60例梗阻性黄疸手术患者分为治疗组32例,对照组28例。治疗组术后辅以阿拓莫兰治疗,对照组为常规治疗。观察两组患者临床症状及体征恢复情况、肝功能、平均住院天数、术后排气时间等。结果治疗组肝功能各项指标包括血清ALT、AST、γ-谷氨酰转肽酶(γ-GT)、碱性磷酸酶(ALP)、血清总胆红素(TB)、直接胆红素(DBil)恢复明显优于对照组(P<0.05),临床症状及体征明显轻于对照组,平均住院天数、术后排气时间短于对照组,但无统计学意义。结论阿拓莫兰对梗阻性黄疸手术患者术后肝功能损害恢复有确切治疗作用。Objective To evaluate the protection of reduced glutathione and clinical therapeutic efficacy in postoperative patients with obstructive jaundice. Methods A randomized controlled trial of parallel design, 60 patients with postoperative obstructive jaundice were divided into treatment group （n^-32） and control group （n=28）. The treatment group was treated by reduced glutathione, the control group was treated by routine methods, clinical symptoms, signs, the average number of hospital days and aerofluxional time were observed in the two groups. Results ＂ The index of the liver function in the treatment group including serum glutamate-pyruvate transaminase （ALT）, aspartic acid transaminase （AST）, r-glutamyl transpeptidase （ v -GT）, alkaline phosphatase （ALP）, and serum total bilirubin （TB）, direct bilirubin （DBil） were obviously better than that in the control group （P〈0.05）, clinical symptoms and objective sign were clearly light versus the control group, the average number of hospital days and aerofluxional time were short versus the control group, but not statistically significant. Conclusion Reduced glutathione on treating patients with postoperative obstructive jaundice, there is obvious therapeutic effects in the liver function restoration.

关 键 词：胆管梗阻 肝外 手术后并发症 肝疾病 谷胱甘肽 药物治疗 

分 类 号：R657.4[医药卫生—外科学]