健骨方治疗绝经后骨质疏松症临床研究  

Clinical Study about Treatment of Postmenopausal Osteoporosis with Jiangu Recipe

作　　者：邱仁斌[1] 沈瑞子[1] 张培钦[1] 陈远林[1] 叶红萍[1] 张琰[1] 

机构地区：[1]深圳市龙岗中心医院,广东深圳518116

出　　处：《中华中医药学刊》2008年第7期1529-1530,共2页Chinese Archives of Traditional Chinese Medicine

基　　金：深圳市科技计划项目(2005274)

摘　　要：目的:观察健骨方治疗绝经后骨质疏松症(PMOP)的疗效,并探讨其作用机制。方法:选取120例PMOP患者,随机分为两组,治疗组给予健骨方口服,对照组给予口服固邦10mg/天,6个月为1个疗程。治疗前后进行症状评分,观测骨密度(BMD),骨钙素(BGP),雌二醇(E2),白细胞介素6(IL-6)。结果:治疗1年后,治疗组临床总有效率91.7%,明显优于对照组53.3%(P<0.01),BMD、BGP、E2明显增加(P<0.05),IL-6明显降低(P<0.05)。结论:健骨方能改善临床症状,增加雌激素水平,提高骨密度,促进骨形成,对PMOP具有较好的治疗作用。Objective： To explore the effect of Jiangu recipe on the patients with postmenopausal osteoporosis （PMOP） and its mechanism. Methods： The 120 patients of PMOP were randomly divided two groups. The treatment group was administered Jiangu recipe while the control group was given Gubang（10mg/d）. A period of treatment was 6 months. The levels of BMD, BGP, E2 and IL -6 before and after treatment were observed. Results： After a year, the total effective rate in the treatment group was significantly higher than in the control group,91.7% vs 53.3% （ P 〈 0.01 ）. And the treatment group was also significantly better than the control group in increasing BMD, BGP and E2 （ P 〈 0.05） , and decreasing IL- 6 （ P 〈 0.05）. Conclusion： Jiangu recipe can significantly improve the symptoms and increase the levels of BMD, BGP and E2. It is good for PMOP.

关 键 词：骨质疏松症 绝经后 中医药疗法 健骨方 

分 类 号：R591.44[医药卫生—内科学] R271.116[医药卫生—临床医学]