一种含有拟冠醚结构双子型肽脂质的合成改进  

Improvement on synthesis of a gemini lipid with pseudo-crown ether

作　　者：赵明明[1] 王剑锋[2] 范圣第[2] 

机构地区：[1]大连理工大学环境与生命学院生物科学与工程系,辽宁大连116024 [2]大连民族学院生命科学学院生物技术与资源利用国家民委-教育部重点实验室,辽宁大连116600

出　　处：《化学试剂》2008年第7期547-549,共3页Chemical Reagents

基　　金：国家自然科学基金资助项目(20472013)

摘　　要：针对以2,5,8,11-四氧十二烷二酰基(TEO)连接的含有组氨酸残基的双子型肽脂质化合物N2,N2′-2,5,8,11-四氧十二烷二酰-双(N,N-双十六烷基-L-组氨酰胺)合成收率低的问题进行了改进。首先去掉双十六烷基-L-组氨酰胺上伯胺基和咪唑基团上叔丁氧羰基(Boc)或对甲苯磺酰基(Tos)的保护,然后与TEO再进行反应,反应后的产物分离纯化容易,收率可达58%。An improvement was made to solve the low yield of a synthetic 2, 5, 8, 11-tetraoxado-decanedioyl-connected gemini peptide compound, N^2, N^2＇-2, 5,8,11- yl-bis （ N, N-dihexadecyl-L-histidinamide）, containing histidine residues. Prior to the reaction with N^2, N^2＇-2, 5,8,11-tetraoxadode-canedioyl chloride for manufacturing the desired product, the protection groups Boc or Tos of p-amine and imidazole groups of N, N-dihexadecyl-L-histidinamide were removed. The desired product could be easily separated at a yield of 58 %, which was higher than the literature reported value of 22 %.

关 键 词：双子化合物 肽脂质 眯唑基 组氨酸 

分 类 号：O626.23[理学—有机化学]