佳乐施与万汶在高位脊髓损伤患者手术中的应用  

Perioperative use of Gelofusine and Voluven in Patients with High-Level Spinal Cord Injury

作　　者：李正[1] 袁红斌[2] 陆小芳[1] 顾勇伟[1] 纪健[1] 朱涛[1] 

机构地区：[1]上海市松江区中心医院麻醉科,上海201600 [2]上海市长征医院麻醉科,上海200003

出　　处：《郧阳医学院学报》2008年第3期242-244,共3页Journal of Yunyang Medical College

摘　　要：目的:比较佳乐施和万汶在高位脊髓损伤患者手术中应用的有效性和安全性。方法:60例高位脊髓损伤手术患者,随机分成万汶(羟乙基淀粉)组、佳乐施(琥珀酰明胶)组和血浆组。监测术前10min、手术开始1h、手术结束即刻、术后4h、术后8h患者心排血量指数(CI)、心脏舒张末血容量指数(GEDVI)、平均动脉压(MAP)及血管外肺水指数(EVLWI),计算患者氧供(DO2)和氧耗(VO2)。结果:与术前10min时比较,3组患者的MAP平稳,CI、DO2、VO2、GEDVI均增加。万汶组在手术后8h,GEDVI较佳乐施组有明显下降(P<0.01)。结论:佳乐施维持循环血容量充足、维护血流动力学稳定、保证氧供/氧耗平衡的疗效,效果优于万汶。Objective To evaluate efficacy and safety of Gelofusine and Voluven in perioperative period in patients with high - level spinal cord injury. Methods Sixty patients with high - level spinal cord injury were randomly divided into 3 groups （ n =20） ： Voluven group,Gelofusine group,plasma group. Mean arterial pressure （MAP） ,cardiac index （CI） ,global end diastolic volume index （GEDVI）, extravascular lung water index（EVLWI） were measured 10 minutes after intubation, 1 hour after initiation of operation,immedlately after the end of operation ,4 and 8 hours after the operation. Meanwhile, oxygen delivery（ DO2） and the oxygen consumption（ VO2 ） were calculated at the corresponding time points. Results in all groups, MAP was stable, and CI,DO2 ,VO2 ,GEDVI was increased. The GEDVI was lower in Voluven group than in Gelofusine group at 8 hours after the operation. Gonclusions Gelofusine is better than Voluven in maintaining the stability of hemodynamics, expanding the plasma volume, and improving the DO2/VO2 of the body.

关 键 词：液体治疗 万汶 佳乐施 

分 类 号：R614[医药卫生—麻醉学]