113例药物性肝病的药物相关性分析  

Correlation Analysis of 113 Patients with Drug-induced Liver Disease

作　　者：邸岩[1] 倪杰[1] 齐颖[1] 马进玉[1] 

机构地区：[1]北京世纪坛医院,北京市100036

出　　处：《中国药房》2008年第20期1577-1578,共2页China Pharmacy

摘　　要：目的：对113例药物性肝病患者进行分析，以验证国际共识标准的，临床实用价值。方法：通过回顾性分析，对2006～2007年在我院诊断为药物性肝病的患者113例按照国际药物性肝损害分型标准进行，临床分型，采用Maria标准及DDW—J标准进行评分，分析发生药物性肝病的药物相关性。结果：药物性肝病占同期住院的肝病病例的13．7％（113／822），其中肝细胞损害型占15．0％（17／113），胆汁淤积型占81．4％（92／113），混合型占3．5％（4／113）。Maria标准及DDW—J标准得出药物与肝病相关性的结论不尽相同。引起药物性肝病的药物主要是降脂药和免疫抑制剂，抗凝剂居第3位。结论：DDW—J标准与临床诊断比较接近，规范了药物性肝病的诊断标准，但是也有一定的局限性。OBJECTIVE： To analyze 113 patients with drug- induced liver disease （DILD） so as to clinically validate the international generally accepted diagnostic criteria. METHODS： 113 DILD cases were reviewed and categorized according to international generally- accepted diagnostic criteria and then graded separately by Maria clinical scale and DDW J scale to analyze the correlations. RESULTS： 113 out of 822 patients with liver diseases were DILD （13.7%）, among whom 17 were of hepatocellular type （15.0%）, 92 cholestasis type（81.5% ） and 4 mixed type （3.5%） . Application of Maria clinical scale and DDW J scale led to different number of DILD cases diagnosed. DILD were mostly induced by antihyperlipidemic drugs and immunosuppressants followed by anticoagulant drugs. CONCLUSION： DDW-J scale, which is more close to clinical diagnostic criteria, contributed to the standardization of the diagnostic criteria of DILD, yet it has its limitations as well.

关 键 词：药物性肝病 药物相关性 Maria标准 DDW—J标准 

分 类 号：R969.3[医药卫生—药理学]