诺氟沙星在碳糊电极上的阴极吸附伏安法研究  

Cathodic Adsorptive Voltammetric Determination of Norfloxacin at a Carbon Paste Electrode

作　　者：易兰花[1] 田俐[2] 费俊杰[1] 黎拒难[1] 

机构地区：[1]湘潭大学化学学院,湖南湘潭411105 [2]湖南科技大学化学化工学院,湖南湘潭411201

出　　处：《湘潭大学自然科学学报》2008年第2期45-47,76,共4页Natural Science Journal of Xiangtan University

基　　金：中科院长春应化所电分析化学国家重点实验室基金(SKLEAC200510);湖南省教育厅青年基金(05B004)资助项目

摘　　要：报道了用碳糊电极阴极吸附伏安法测定诺氟沙星的方法.在B-R(pH=8.0)缓冲液中,诺氟沙星在碳糊电极(CPE)上有一灵敏的吸附还原峰,峰电位为-1.12V(vs.SCE).氧化峰的二阶导数峰电流与诺氟沙星的浓度在8.0×10-9～2.0×10-7mol/L(富集90s)范围内呈良好的线性关系,相关系数为0.9946,检出限为4.0×10-9mol/L(S/N=3,富集110s),探讨了诺氟沙星在碳糊电极上的伏安性质和电极反应机理,并且成功应用于胶囊中诺氟沙星含量的测定与回收.A highly selective and rapid cathodic adsorptive voltammetric method was developed for the determination of trace amount of norfloxacin at a carbon paste electrode （CPE）. The norfloxacin was adsorbed on the surface of the CPE in B-R buffer solution （pH=8.0） yielding one reduction peak at -1.12 V （vs. SCE）. The relationship between the peak current and norfloxacin concentration is linear in a range of 8. 0×10^-9～2.0×10^-7mol/L with a correlation coefficient 0. 994 6. The detection limit is 4.0× 10^-9 mol/L （ S/N =3） for 110 s acummulation. The electrode reaction mechanism of norfloxacin was investigated. The proposed method was applied to direct determine trace norfloxacin in the capsules with satisfied results.

关 键 词：诺氟沙星 阴极吸附伏安法 碳糊电极 

分 类 号：O657.1[理学—分析化学]