动态血压监测评价不同给药时间对老年高血压患者降压效果的影响  

Evaluation of depressurization effect on gerontism hypertension at different administration times with ambulatory blood pressure monitoring

作　　者：薛晓荣[1] 

机构地区：[1]北京中医药大学附属护国寺中医院内科,北京100034

出　　处：《山西医科大学学报》2008年第7期644-646,共3页Journal of Shanxi Medical University

摘　　要：目的研究不同时间给药对老年高血压病患者降压效果的影响,寻找合理的给药时间。方法经动态血压监测血压状态属非杓型的高血压病人70例随机分成两组,分别于早上及晚上给予两组病人苯磺酸氨氯地平片治疗8周,同时进行24h动态血压监测,记录各组病人治疗前后的血压情况,特别是夜间和白天平均血压变化,将两组治疗前后动态血压变化参数进行统计分析。结果两组血压均平稳有效地降低,且组间比较无统计学差异(P>0.05)。晚上服药组对改变血压昼夜节律与早上服药组有统计学差异(P<0.05)。结论晚上服药组改变高血压病患者昼夜节律优于早上服药组。Objective To compare the influence of different administration times on gerontism hypertensive, and to explore a rational and effective time of administration. Methods Seventy patients with non-dipper type hypertension were randomly divided into two groups. The patients were given amlodipine besylate tablet for 8 weeks in the morning and at night in two groups, respectively. The 24 h ambulatory blood pressure was monitored. Blood pressure was recorded before and after treatment. Results The blood pressure decreased steadily and effectively in two groups, and there was no significant difference between two groups（ P 〉0.05）. The changes of diurnal rhythm of blood pressure had significant difference between those after administration at night and in the morning （P 〉0.05）. Conclusion Administration at night is better to change diurnal rhythm of blood pressure and control hypertension than administration in the morning.

关 键 词：动态血压监测 高血压 随机对照研究 

分 类 号：R544.1[医药卫生—心血管疾病]