缺血性脑卒中中医证型与AGT基因M235T多态性的相关性  

Association Between Syndromes Defined by Traditional Chinese Medicine in Cerebral Infarction and Angiotensinogen Gene M235T Polymorphism

作　　者：黄蓓[1] 邵卫[1] 董梦久[1] 涂晋文[1] 王林[1] 

机构地区：[1]湖北省中医院神经内科,湖北武汉430061

出　　处：《武汉大学学报（医学版）》2008年第4期482-484,507,共4页Medical Journal of Wuhan University

基　　金：国家自然科学基金资助项目(编号:30572392)

摘　　要：目的:探讨缺血性脑卒中风痰瘀血、痹阻脉络证及肝阳暴亢、风火上扰证与血管紧张素原(AGT)基因M235T多态性的相关性。方法:运用聚合酶链反应-限制性片段长度多态性分析法(PCR-RFLP)对104例脑梗死患者进行AGT M235T多态性的基因型及等位基因频率分布研究。结果:两组基因型频率χ2=1.04,P>0.05,等位基因频率χ2=1.14,P>0.05。结论:基因型频率及等位基因频率分布在风痰瘀血、痹阻脉络证及肝阳暴亢、风火上扰证之间的差别无明显统计学意义。Objective： To explore the association between two syndromes（phlegm and blood stasis syndrome and predominant liver yang syndrome） defined by traditional Chinese medicine in cerebral infarction and angiotensinogen（AGT） the gene M235T polymorphism.Methods： M235T polymorphism of AGT gene from peripheral blood leukocytes was examined in 104 cases with cerebral infarction by polymerase chain reaction（PCR） amplification and restriction fragment length polymorphism（RFLP）.Results： There were no statistical difference in frequencies of genotype and allele between the two groups（χ^2=1.04,P〉0.05,χ^2=1.14,P〉0.05）.Conclusion： The frequencies of genotype and allele distributes in the two syndromes as mentioned above have no obvious statistics significance.

关 键 词：缺血性脑卒中 中医证型 AGT基因M235T多态性 PCR-RFLP 

分 类 号：R255.2[医药卫生—中医内科学]