川芎嗪治疗胎儿生长受限的临床疗效  

Clinical Effects of Tetramethylpyrazine in the Treatment of Fetal Growth Restriction

作　　者：张正娥[1] 王燕[1] 张元珍[1] 李家福[1] 

机构地区：[1]武汉大学中南医院妇产科,湖北武汉430071

出　　处：《武汉大学学报（医学版）》2008年第4期538-541,共4页Medical Journal of Wuhan University

基　　金：湖北省科技攻关项目(编号:2003AA301C38)

摘　　要：目的:探讨川芎嗪防治胎儿生长受限(FGR)的临床疗效。方法:将34例FGR孕妇随机分为川芎嗪组17例(A组)和营养支持组17例(B组),另外选择同期在我院定期产检并分娩的正常孕妇30例作为正常妊娠对照组(C组)。A组给予营养支持治疗的同时加用川芎嗪注射液治疗,B组仅予以相同的单纯营养支持治疗,7 d为1疗程;C组除左侧卧位外,不予以其他处理。监测胎儿生长发育参数、脐动脉血流及围产儿结局。结果:治疗后,A组测量的胎儿各生长径线值、新生儿出生体重明显高于B组,而脐血流阻力指标与B组相比明显下降,均有显著性差异。结论:川芎嗪能明显改善FGR孕妇子宫胎盘血流灌注,促进胎儿生长发育,川芎嗪结合营养支持较单纯的营养支持治疗具有更好的临床疗效。Objective： To assess the clinical effect of tetramethylpyrazine in treating fetal growth restriction（FGR）.Methods： Thirty-four pregnant women were randomly and equally divided into tetramethylpyrazine group and nutritional support group.Another 30 healthy pregnant women were involved in the normal control group.Fetal growth parameters,umbilical artery blood flow velocity and perinatal infant prognosis were measured and compared among these three groups.Results： After treatment,the fetal growth parameters and newborn average birth weight of tetramethylpyrazine group were significantly higher than those of nutritional support group,and umbilical artery blood flow resistance index in tetramethylpyrazine group was lower than that of nutritional support group.Conclusion： Tetramethylpyrazine can obviously improve uterine placenta blood flow of FGR patients,accelerate fetal growth and increase newborn average birth weight.

关 键 词：川芎嗪 胎儿生长受限 

分 类 号：R714[医药卫生—妇产科学]