人阴离子交换器(hURAT1)基因多态性与代谢综合征的关系  

The Association between the Polymorphism of hURAT1 Gene Exon 1 C258T and the Metabolism Syndrome

作　　者：王波[1] 隋少华[1] 张文娟[1] 曲昌华 

机构地区：[1]山东省烟台市烟台山医院,264000

出　　处：《医学研究杂志》2008年第7期63-66,共4页Journal of Medical Research

摘　　要：目的探讨人阴离子交换器(hURAT1)基因外显子1C258T位点多态性与代谢综合征组分的关系。方法该研究分为高尿酸血症组(138例)和健康对照组(117例),两组入选者分别测定身高、体重、腰围、臀围、体质指数、血压等;抽空腹血测血尿酸、血糖、血脂、肝酶、尿素氮、肌酐等。采用聚合酶链反应技术分析hURAT1基因外显子1C258位点多态性;采用方差分析的方法,分析该位点多态性与血尿酸、血糖、收缩压、舒张压、总胆固醇、甘油三酯、体质指数、腰臀围等代谢综合征各组分的相关性。结果CC基因型和CT基因型比较,血尿酸、收缩压、甘油三酯、体重指数、腰臀围比的差异有极显著性意义(P<0.001),总胆固醇、舒张压的差异有显著性意义(P<0.05),空腹血糖的差异无显著性意义。CT基因型和TT基因型比较,血尿酸、收缩压、总胆固醇、体重指数、腰臀围比的差异有极显著性意义(P<0.001),舒张压、甘油三酯、空腹血糖的差异有显著性意义(P<0.05)。结论hURAT1基因外显子1C258T多态性与代谢综合征各组分相关。Objective To investigate the relationship of the polymorphisms of hURATlgene in exon 1 C258T and the compnents of metabolism syndrome. Methods This research is divided into the hyperuricemia groop （ 138 examples） and the healthy matched controls （117 examples） ,which selected of the two groops were determined body high, body medical history;They were checked blood uric acid, fasting blood glucose, blood -fat, hepatic enzyme, urea nitrogen and blood creatinine. Analysis the polymorphisms of hURAT1 gene in exon 1 C258T by polymerase chain reaction technique. Investigate the dependablity beween the blood uric acid, fasting blood glucose, systolic blood pressure, diastolic blood pressure,total chloesterol,triacylglycerol, body mass index, waistline, rump circumference and the different genetypes. Results The differences have statiscal significance in UA, SBP, DBP, TC, TG, BMI, WHR beween the CC gene type and the CT genetype （P 〈0.001 ,P 〈0.05）. But it is not significant in GLU . The differences have great statiscal significance in UA, SBP, TC, BMI, WHR beween the CT genetype and the TT genetype （P 〈0. 001 ）. The differences have statiscal significance in DBP, TG, FPG beween the CT genetype and the TT genetype （P 〈 0. 05）. Conclusion The polymorphisms of S h URATI gene in exon 1 C258T is concerned with the eompnents of metabolism syndrome.

关 键 词：代谢综合征 人阴离子交换器基因 多态现象 

分 类 号：R589[医药卫生—内分泌] R541.4[医药卫生—内科学]