阿片类药物治疗终末期癌痛患者的临床分析  

Cinical analysis of opioid in the therapy of terminal cancer pain

作　　者：王笃平 王莉 陈馨[2] 

机构地区：[1]宝鸡市四零九医院肿瘤科,陕西宝鸡721006 [2]宝鸡市中心医院,陕西宝鸡721008

出　　处：《现代肿瘤医学》2008年第7期1224-1225,共2页Journal of Modern Oncology

摘　　要：目的:分析终末期癌症患者应用阿片类镇痛药物的剂量与安全性。方法:回顾性分析181例终末期癌症患者中138例(76.3%)用阿片类药物镇痛,比较不同性别、年龄、原发肿瘤部位和转移部位阿片镇痛药物疗效及副作用。结果:可评价的138例中,用硫酸吗啡控释片(美施康定)105例(76.1%),芬太尼透皮帖剂(多瑞吉)21例(15.3%),弱阿片类12例(8.7%)。日平均吗啡口服量男性高于女性(P=0.02);随着年龄增大,用药剂量减少(P<0.05),不同部位肿瘤患者用量无明显差异(P>0.05)。用硫酸吗啡控释片发生呼吸抑制需解救者4例(3.8%),便秘发生率11.4%。无药物过量致死亡患者。结论:阿片类镇痛药物使用剂量与性别和年龄有一定关系,原发病灶与剂量无关,不良反应可控制。Objective：To analyze the dosage and safety of opioid in patients with cancer pain. Methods：To analyze canaer pain treatment in patients with terminal cancer treated by oploid. Results ：Among 138 cases received opioid therapy, 105 cases （76.1%） received releasing control morphine sulfate （ ms - contin） and 21 cases （ 15.3% ） accepted transdermal fentanyl. Weak opioids were administered for 12 cases （8.7%）. There was a significant increase in total daily mean dosage of oral morphine in male compared to female patients, the older the patients were, the lower dosage they needed, no correlationship was found between primary tumor sites and opioid dosage, no patients were died of opioid usage. Conclusion： There was some relationship among the opioid dosage and gender and age, primary foci of tumor was not associated with opioid dose,the side effects can be controlled.

关 键 词：癌痛 治疗 阿片 

分 类 号：R730.53[医药卫生—肿瘤]