克林霉素磷酸酯体外抗菌作用  

The antibacterial action of clindamycin phosphate in vitro

作　　者：曹筝[1] 王莹[1] 严杰[2] 

机构地区：[1]杭州市第三人民医院口腔科,310009 [2]浙江医科大学微生物教研室

出　　处：《口腔材料器械杂志》1997年第3期110-111,140,共3页Chinese Journal of Dental Materials and Devices

摘　　要：本文报告克林霉素磷酸酯时208株厌氧菌和204株需氧菌的体外抑菌试验结果。克林霉素磷酸酯经碱性磷酸酶水解后可释放克林霉素,其抗菌效果和抗菌谱与克林霉素对照药相接近。克林霉素磷酸酯对革兰氏阳性厌氧和需氧菌的抑菌效果明显优于林可霉素和甲硝唑。对于革兰氏阴性厌氧菌,克林霉素磷酸酯抗菌作用不如甲硝唑。由于克林霉素磷酸酯可用于注射,且副作用较小,故可成为临床上抗革兰氏阳性厌氧菌和需氧或兼性厌氧菌感染的十分有效的药物。The paper reported the bacteriostatic experimental result in vitro of clindamycin phosphate (CD桟 ) for anaerob and aer-obes. CD ?P could release clindamtcin (CD)after alkaline phosphatose's hydrolysis, whose antiseptic effect and antimicronial spectrum is similar to control drug of CD. The bacteriostatic effect of CD-P for bram ?positive aerobe and anaerobe had more protity over Lineomycin's ( LC ) and Metronidazone's (MTZ), but it was inferior to MTZ for gram ?negative anaerobe, CD -P could be used to inject ,and had a little side effect, so it could become effective drugs against infection of gram ?positive anaerobe and aerobe or facultative anaerobe.

关 键 词：克林霉素磷酸酯 细菌 感染 口腔药物 

分 类 号：R988.2[医药卫生—药品]