颈动脉狭窄支架置入前后同型半胱氨酸变化及与再狭窄的关系  

Study on the relationship between the levels of plasma homocystein and the restenosis of carotid artery stenosis

作　　者：朱青峰[1] 王国芳[1] 王千[1] 边世春[1] 

机构地区：[1]解放军第264医院神经外科,太原030001

出　　处：《中国实用神经疾病杂志》2008年第7期29-31,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的观察颈动脉狭窄血管内支架置入前后血浆同型半胱氨酸的水平及其与再狭窄的关系。方法2006—07～2007-10应用血管内支架成型术治疗颈动脉狭窄21例，于术前1d、术后1d和3个月查血浆Hcy水平及脑血管造影，对血浆Hcy水平及血管再狭窄情况进行分析。结果21例颈动脉狭窄患者支架置入前后血浆Hcy水平无明显差别，（20．77±7．15）μmol／Lvs（21．71±7．53）μmol／L（P〉0．05），（19．87±7．29）μmol／L vs （21．951±6．98）μmol／L（P〉0．05）；但术后3个月复查时再狭窄组血浆Hcy水平高于未狭窄组，（27．53±8．73）μmol／L vs（20．67±7．32）μmol／L（P〈0．01），差别有统计学意义。结论颈动脉狭窄血管内支架置入术后血浆Hcy水平升高可能是再狭窄的危险因素之一。Objective To observe the relationship between the levels of plasma homocystein and the restenosis of carotid artery stenosis after stent implantation. Methods Twenty-one patients with symptomatic carotid artery stenosis were treated between July 2006 and October 2007, the levels of plasma homocysteine and restenosis were determined before and after stent implantation one day and 90 days. Results The levels of plasma homocysteine of symptomatic carotid artery stenosis had no difference before and after stent implantation one day, （20. 77±7. 15）μmol/L vs （21. 71±7.53） μmol/L（P〈0. 05）, （19.87±7.29） μmol/L vs （21. 951±6.98）μmol/L（P〉0.05）; The levels of plasma homocysteine of restenosis after stent implantation 90 days were higher than that of no restenosis, （27. 53±8.73） μmol/L vs （20. 67±7.32） μmol/L （P〈0.01）. Conclusion The levels of plasma homocysteine in symptomatic carotid artery stenosis after stent implantation 90 days are higher, hyperhomocystein is associated with the restenosis after stent implantation to symptomatic carotid artery stenosis.

关 键 词：颈动脉狭窄 血管内支架成型术 同型半胱氨酸 再狭窄 

分 类 号：R543.4[医药卫生—心血管疾病]