环原黄杨星A对心房纤颤的作用(英文)  

Effects of cycloprotobuxine-A on atrial fibrillation

作　　者：汪永孝[1] 郑云敏 谭月华[1] 盛宝恒 

机构地区：[1]第四军医大学药理教研室 [2]第四军医大学空军医学系

出　　处：《中国药理学报》1997年第3期250-250,共1页Acta Pharmacologica Sinica

摘　　要：目的:研究环原黄杨星A(Cyc-A)抗心房纤颤的作用.方法:用药物诱发心房纤颤;用微电极技术记录动作电位.结果:Cyc-A对抗CaCl_2-ACh诱发的在体心房纤颤和乌头碱等诱发的离体心房纤颤,并与胺碘酮作用相似.Cyc-A抑制窦房结细胞的自律性和异丙肾上腺素引起的自律性增加.对离体左心房,Cyc-A抑制肾上腺素引起的异常自律性,延长APD和ERP,降低兴奋性;高浓度时还可降低V_(max)· Cyc-A能拮抗ACh所致的APD缩短.胺碘酮有相似的作用,但对V_(max)无影响.结论:Cyc-A抗心房纤颤的作用是通过延长复极、降低自律性和抑制兴奋性而产生.AIM: To study the effects of cycloprotobuxine-A (Cyc-A) on atrial fibrillation. METHODS: Atrial fibrillations in vivo and in vitro were induced by arrhythmogenic drugs. Action potentials were measured by the standard microelectrode technique. RESULTS: Cyc-A, similar to or slightly stronger than amiodarone (Ami), decreased incidences of atrial fibrillation elicited by CaCl2-acetylcholine in mice and increased doses of aconitine, ouabain, or adrenaline to elicit atrial fibrillation in isolated guinea pig atria. Cyc-A 0.3 - 100 μmol · L-1 decreased the normal automaticity and 0.3 - 30 μmol ·L-1 attenuated or almost abolished the isoprenaline-induced abnormal increase in automaticity in sinus nodal cells. In isolated left atria, Cyc-A 0.3 - 30 μmol · L-1 inhibited the abnormal rhythmic activity elicited by adrenaline, prolonged action potential duration (APD) and effective refractory period, and reduced excitability. At 3 - 30 μmol · L-1, Cyc-A also decreased the maximal velocity of depolarization ( Vmax) · Cyc-A antagonized the acetylcholine-induced shortening of APD. These electrophysiologic effects were similar to those of amiodarone, but Ami did not affect the Vmax. CONCLUSION: Cyc-A produces a protective effect against experimental atrial fibrillation via a prolongation of repolarization, a decease of automaticity, and an inhibition of excitability.

关 键 词：环原黄杨星A 心房纤颤 

分 类 号：R972[医药卫生—药品] R541.75[医药卫生—药学]