人血浆中总铂的石墨炉原子吸收测定方法研究  

Determination of carboplatin in plasma by graphite furnace atomic absorption spectrophotometry

作　　者：赵玮[1] 张敬[1] 杜会芳[1] 李春玲[1] 闫慧芳[1] 

机构地区：[1]中国疾病预防控制中心职业卫生与中毒控制所,北京100050

出　　处：《中国卫生检验杂志》2008年第6期988-989,1029,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的：建立石墨炉原子吸收测定法检测人血浆中总铂浓度。方法：样品采用1%HNO3直接稀释的方法进行预处理,自动进样器直接进样,测定样品中总铂浓度。结果：铂浓度在0～2000μg/L范围内时,方法线性良好,线性相关系数为0.9998,检出限为13μg/L,RSD范围为2.0%～9.4%,平均回收率范围为99.71%～101.6%。结论：方法前处理过程简便,样品用量少,灵敏度高,适用于经铂类抗癌药物治疗后肿瘤患者血药浓度的日常监测。Objective：A method was established for determination of platinum in plasma by graphite furnace atomic absorption spectrophotometry. Methods：Samples were only diluted by 1% HNO3. Through optimizing the operating conditions of the instrument, the platinum in plasma was directly determined by GF- AAS. Results：A good linear correlation was found at a concentration of 0 -2000 μg/L. The correlation coefficient was 0. 9998. The detection limit was 13 μg/L and the RSD range was 2. 0% - 9.4%. The range of average recovery was 99. 71% - 101.6%. Conclusion：The method is simple and shows high sensitivity and good precision. So it is suitable for the determination of platinum in plasma of cancer patients who received therapy.

关 键 词：石墨炉原子吸收 铂 人血浆 

分 类 号：O657.31[理学—分析化学]