双重乳液/溶剂蒸发法制备超声造影微泡  

Preparation of Ultrasound Contrast Microbubbles via Double Emulsion/Solvent Evaporation Process

作　　者：陆蓉[1] 窦红静[1] 孙康[1] 

机构地区：[1]上海交通大学材料科学与工程学院,金属基复合材料国家重点实验室,上海200240

出　　处：《高等学校化学学报》2008年第6期1176-1180,共5页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:30600751)资助

摘　　要：通过水包油包水(W1/O/W2)双重乳液的油相溶剂蒸发过程,制备了聚左旋乳酸(PLLA)微泡,结合扫描电子显微镜(SEM)、激光共聚焦显微镜(LCSM)和粒度分析(PSA)等表征手段,研究了外水相乳化剂的种类、浓度、两次乳化的水油比、均质机转速等参数对微泡性能的影响.研究结果表明,聚乙烯醇(PVA)是该体系外水相有效的乳化剂;通过调节PVA水溶液的浓度或第二次乳化时均质机转速,能有效地控制微泡的平均粒径(1～10μm);第一次乳化的水油比是微泡空心率的重要影响因素.对微泡负压充气后,进行体外超声显影检测,证明该微泡具有较好的超声造影增强效果.In this paper, water in oil in water（W1/O/W2） double emulsion/solvent evaporation process was used to prepare poly （L-lactic acid ） （PLLA） microbubbles. With the characterization technique of SEM, CLSM and PSA, we investigated how the experimental parameters would influence the properties of microbubbles. The results demonstrate that poly（ vinyl alcohol） （PVA） was an excellent emulsifier in the outer aqueous phase for this system. By changing the concentration of PVA aqueous solution or the speed of homogenizer during the second emulsification, the average size of microbubbles can be controlled between 1 μm to 10 μm. The ratio of water to oil at the first emulsification will affect the hollow ratio of microbubbles to a great extent. It was confirmed that gas-filled PLLA microbubbles has an excellent ultrasound contrast ability.

关 键 词：微泡 双重乳液 聚左旋乳酸(PLLA) 超声造影 

分 类 号：O648.23[理学—物理化学] TB324[理学—化学]