泼尼松所致大鼠骨质疏松的骨密度和力学性能测定  

Bone density and biomechanical characters of prednisone acetate induced osteoporosis in rats

作　　者：廖进民[1,2] 朱青安[1,2] 卢海俊 李青南 吴铁[1,2] 黄莲芳 

机构地区：[1]广州市第一军医大学临床解剖学研究所 [2]广东医学院骨生物学研究室

出　　处：《中国临床解剖学杂志》1997年第3期215-217,共3页Chinese Journal of Clinical Anatomy

摘　　要：目的：测定泼尼松所致大鼠骨质疏松的骨密度和力学性能。方法：采用１６只３月龄雄性ＳＤ大鼠，体重３４５～３４７ｇ，随机分为对照组和实验组，后者喂醋酸泼尼松４．５ｍｇ／ｋｇ，２次／周。９０天后对两组动物股骨分别进行单光子骨密度测定和扭转试验。结果：实验组股骨近段、中段和远段的骨密度分别减少了１２．４％（Ｐ＜０．０５）、１３．９％（Ｐ＜０．０５）和１１．９％（Ｐ＜０．０５）；股骨干抗扭转各项指标均出现减少趋势。结论：长期使用ＧＣ，会导致骨矿含量减少，由于骨的构筑发生了改变，使其抵抗扭转的能力降低。Objective: To evaluate bone density and biomechanical characters of prednisone acetate induced osteoporosis in rats. Methods: Sixteen male Sprague Dawley rats were randomly divided into two groups, and prednisone acetate (4.5mg/kg) were gave to experimental group twice a week.After 90 days, single photon absorptiometric test and torsion tests were made on femurs of two groups.Results: Bone densities of proximal,middle and distal segments of femurs in experimental group were significantly decreased (P<0.05) than that of control group.The torsion strength of the experimental femurs had a decreased tendency.Conclusions:When glucocorticoid used for a long time,fracture would easily happened due to bone density decrease.

关 键 词：醋酸泼尼松 骨质疏松 骨密度 生物力学 

分 类 号：R977.11[医药卫生—药品] R681.04[医药卫生—药学]