新生儿急性肺损伤时血清IL-8和TNF-α的变化及其意义  

Serum levels of interleukin-8 and tumor necrosis factor alpha in newborn infants with acute lung injury

作　　者：林振浪[1] 周微[1] 陈春[1] 余波[1] 梁志强[1] 刘江勤[1] 

机构地区：[1]温州医学院附属育英儿童医院新生儿科,浙江温州325027

出　　处：《中国急救医学》2008年第6期544-546,共3页Chinese Journal of Critical Care Medicine

摘　　要：目的通过测定新生儿急性肺损伤(ALI)时血清白细胞介素-8(IL-8)和肿瘤坏死因子-α(TNF-α)水平,探讨细胞因子在评估新生儿ALI中的作用。方法采用酶联免疫吸附实验方法测定28例胎粪吸入综合征患儿血清IL-8和TNF-α水平,同时与新生儿肺透明膜病患者和对照组的水平进行比较,并在疾病恢复期复测。结果①胎粪吸入综合征组入院时血清中IL-8水平中位数为174.00pg/mL,与新生儿肺透明膜病组和对照组比较明显增高(P<0.01);治疗后疾病恢复期血清IL-8水平为24.80pg/mL,与入院时比较显著下降(P<0.01);②入院治疗前胎粪吸入综合征组TNF-α水平中位数为25.90pg/mL,显著高于原发性肺透明膜病组(P<0.01),但与对照组比较差异无统计学意义(P>0.05);恢复期TNF-α水平为20.22pg/mL,较入院时差异无统计学意义(P>0.05)。结论IL-8在新生儿ALI的炎症反应中有着重要的作用,其血清细胞因子水平的下降预示着疾病的好转。Objective To determine the serum levels of interleukin-8（IL-8）and tumor necrosis factor alpha（TNF-α）in order to investigate their effects on newborns with acute lung injury（ALI）.Methods The serum levels of IL-8 and TNF-α in 28 newborns with ALI were determined by ELISA and the result was compared with those of hyaline membrane disease（HMD）and control group.Results ①The median of serum IL-8 in meconium aspiration syndrome（MAS）were 174.00 pg/mL when the patients were admitted to hospital,which was significantly higher than those in HMD and the control group（P〈0.01）.During the recovery stage of the disease,the level of IL-8 decreased significantly（P〈0.01）.②The median level of TNF-α in MAS at the beginning was 25.90 pg/mL,which was much higher than that in HMD（P〈0.01）,but there were no significant changes in TNF-α during the recovery stage of the disease（P〉0.05）.Conclusion Interleukin-8 plays an important role in inflammatory response of newborn infants with acute lung injury,and its decrease predicts the recovery of disease.

关 键 词：白细胞介素-8 肿瘤坏死因子-Α 新生儿 急性肺损伤 

分 类 号：R722.1[医药卫生—儿科]