急性心肌缺血、再灌注对兔红、白细胞流变学影响及硝苯啶对其保护作用实验研究  

THE INFLUENCE OF ACUTE MYOCARDIAL ISCHEMIA-REPERFUSION INJURY ON RBC AND WBC RHEOLOGY AND THE EXPERIMENTAL RESEARCHES OF NIFIDIPINE PROTECTION

作　　者：刘明远[1] 王月燕[1] 刘改香 

机构地区：[1]解放军济南医学高等专科学校,山东250022

出　　处：《中国血液流变学杂志》1997年第3期8-11,共4页Chinese Journal of Hemorheology

摘　　要：在兔急性心肌缺血及再灌注情况下，我们用上海医科大学研制的 ＤＸＣ—４００型核孔滤膜细胞变形能力测定仪观察了兔红白细胞流变学变化，并用 一组动物术前给予硝苯啶药物，观察了此药对红白细胞流变学变化的影响．结果表 明，急性心肌缺血和再灌注情况下，红细胞滤过指数（ＩＦ）和白细胞阻塞离子浓度 （ＣＰ）都显著增高（Ｐ＜０．０１），用药组对红细胞变形能力的保护作用，出现显著效 果（Ｐ＜０．０１）．说明急性心肌缺血和再灌注均能显著改变红白细胞血液变学变 化，硝苯啶药物在改善器官灌流量的作用申，不但能扩张血管降低血压，而且还能 通过稳定红细胞变形能力，实现其对心脏的保护作用．We observed the changes of hemorheology of WBC and RDC in acute myocardial ischemia ?reperfusion injury of rabbit and the Influences of nifidipine on the changes. The rheology of WDC and RDC was measured with nucleopore membrane RDC deformability meter. The results indicated that the IF of RDC and CP of WDC increased evidently (P < 0. 01) after ischemia -reperfusion. The IF of RDC decreased obviously(p < 0. 001) after administration of nifidipine. We concluded that homorheology of RDC and WDC changed decreased obviously(p < 0. 001) after administration of nifidipine. We concluded that homorheology of RDC and WDC changed significantly after myocardial ischemia - reperfusion, and nifidipine could protect heart by increasing the deformability of RDC.

关 键 词：急性 心肌缺血 再灌注 血液流变学 硝苯啶 

分 类 号：R542.2[医药卫生—心血管疾病]