亚硝胺类化合物的致癌作用及预防  

作　　者：朱雨霏[1] 

机构地区：[1]中国医科大学,沈阳110001

出　　处：《环境保护与循环经济》2008年第5期34-35,45,共3页environmental protection and circular economy

摘　　要：介绍了亚硝胺类化合物的来源,致癌作用以及预防其危害的方法。食品中的亚硝胺类化合物主要来源于食品添加剂,另外,鱼、肉、乳制品和蔬菜、水果也含有一定量的亚硝胺类化合物。自然界中广泛存在着硝酸盐和亚硝酸盐,他们进入人体后也能被合成亚硝胺类化合物。亚硝胺类化合物的致癌作用主要是通过其生成氨氮化合物而间接体现的。预防其危害的主要手段是减少亚硝胺类化合物及其前体硝酸盐、亚硝酸盐的摄入和阻断亚硝胺类化合物在体内合成。The essay introduces the sources of nitrosamines, as well as the carcinogenic effect and preventing measures, It is concluded that nitrosamines in food mainly come from food additives. Moreover, fish, meat, dairy products, vegetables and fruits also contain a certain amount of nitrosamines. Nitrosamines also can be synthesized from widely existed nitrate and nitrite in nature when they are taken into human body. The carcinogenic effect of nitrosamines is shown indirectly by its chemical nature, which is easy to generate lively azo-alkyl compounds and ammonia compounds which have carcinogenic activity. The measures of prevention from nitrosamines on the human tumors risk are mainly to reduce the intake amount of nitrosamine, including its precursor-nitrate and nitrite and block the synthesis in human body.

关 键 词：亚硝胺类化合物 肿瘤 硝酸盐 

分 类 号：TS251.7[轻工技术与工程—农产品加工及贮藏工程] TQ616.8[轻工技术与工程—食品科学与工程]