植酸对衰老模型小鼠MDA、SOD和GSH-PX的影响  

Effects of Phytic Acid on MDA,SOD and GSH-PX of Mouse Aging Model

作　　者：赵永焕[1] 任传英[1] 宁桂芝[2] 崔洪斌[3] 

机构地区：[1]黑龙江八一农垦大学食品学院食品科学系,大庆163319 [2]大庆油田总医院营养科,大庆163001 [3]哈尔滨医科大学公共卫生学院营养与食品卫生教研室,哈尔滨150081

出　　处：《中国粮油学报》2008年第3期140-143,共4页Journal of the Chinese Cereals and Oils Association

基　　金：黑龙江省科委项目：高纯度植酸的开发和应用(2004G0780-00)

摘　　要：以D-半乳糖衰老模型小鼠和自然衰老模型小鼠为试验对象,以植酸为受试物,通过检测小鼠体重、血清中的丙二醛(MDA)含量、超氧化物歧化酶(SOD)活性和脑组织中的谷胱甘肽过氧化物酶(GSH-PX)活力,研究植酸的抗氧化活性。结果表明,植酸在灌胃四周的时间内,对小鼠的体重没有明显影响(P>0.05);可极明显降低衰老模型小鼠血清MDA含量(P<0.01),极显著升高衰老模型小鼠血清中SOD活力,低剂量植酸可显著升高小鼠脑组织中GSH-PX活性(P<0.05)。试验结果显示植酸在体内具有显著的延缓衰老和抗氧化作用。Taking the mouse aging model induced by D- galactose and natural mouse aging model as test objects, and using mice body weight, MDA concentration and SOD activity in mouse serum, and the GSH- PX activity in cerebrum as determine indexes, the antioxidation activity of phytic acid was investigated. Results show that phytic acid significantly reduces the MDA concentration （P 〈 0.01 ）, significantly increases the SOD activity in serum （P 〈 0.01 ） and the GSH- PX activity in cerebrum （ P 〈 0.05 ）, while it does not affect the body weight （ P 〉 0.05） in the four weeks of experiment. The conclusion is that phytic acid possesses significant effect of anti - aging and antioxidation in vivo.

关 键 词：植酸 D-半乳糖 抗氧化 小鼠 

分 类 号：S865.9[农业科学—野生动物驯养] S945.26[农业科学—畜牧兽医]