佛椒酊质量标准研究  

Study on quality standard for Fojiaoding

作　　者：杨瑜[1] 刘萍[1] 胡汉昆[1] 罗国庆[1] 陈健[1] 

机构地区：[1]武汉大学中南医院,武汉430071

出　　处：《中国新药杂志》2008年第12期1057-1059,共3页Chinese Journal of New Drugs

摘　　要：目的：建立佛椒酊的质量标准。方法：采用薄层色谱法鉴别佛椒酊中佛手、花椒及白芷;采用高效液相色谱法对制剂中欧前胡素进行定量分析。结果：在薄层色谱中均能检出佛手、花椒、白芷;欧前胡素在6.08~30.40μg.mL-1范围内浓度与峰面积呈良好的线性关系（r=0.999 9）;平均回收率为99.8%,RSD=2.2%（n=6）。结论：本实验所建立的方法准确、可靠,专属性强,可有效控制制剂质量。Objective：To establish the quality standard for Fojiaoding. Methods：The herbal constituents in the Fojiaoding were separated by TLC. The imperatorin content in Fojiaoding was determined by HPLC. Results： Fructus citri sarcodactylis,Pericarpium zanthoxyli,Radix angelicae dahuricae were obtained by TCL. The standard curve was linear in the range of 6.08 - 30.40μg.mL-1 （ r = 0. 999 9）. The average recovery was 99.8% （ RSD = 2.2% , n =6）. Conclusion：The established method is accurate,reliable and specific,and can be used for quality control of Fojiaoding.

关 键 词：佛椒酊 质量标准 欧前胡素 高效液相色谱 薄层色谱 

分 类 号：R927.2[医药卫生—药学] R943.3