盐酸甲氯芬酯用于治疗颅脑损伤所致昏迷的疗效观察  

The clinical observation of meclofenoxate hydrochloride in treatment of coma by craniocerebral injury

作　　者：高鸿[1] 赵楠[1] 田静[1] 苏平[1] 刘俊[1] 岑建昌[1] 孙敏[1] 

机构地区：[1]昆明市第一人民医院神经外科,云南昆明650011

出　　处：《中国医药导报》2008年第16期70-71,共2页China Medical Herald

摘　　要：目的:观察甲氯芬酯治疗重度颅脑损伤的催醒疗效及安全性。方法:将200例因颅脑损伤所致昏迷的患者(Glasgow评分4～8分)随机分为两组,均予常规治疗,包括依手术指征清除颅内血肿、去骨瓣减压术,脱水降颅内压治疗,以及接受糖皮质激素和抗炎及支持治疗等。治疗组(盐酸甲氯芬酯治疗组)100例患者在对照组(常规治疗组)基础上加用盐酸甲氯芬酯。然后根据Glasgow评分进行评价。结果:治疗组Glasgow昏迷评分(GCS)升高较对照组有显著差异(P<0.05),治疗过程中未见不良反应发生。结论:盐酸甲氯芬酯对治疗重型颅脑损伤后昏迷的催醒治疗有确切的疗效,而且是安全的一种药物。Objective：To explore the clinical efficacy and security of meclofenoxate hydrochloride on coma caused by craniocerebral injury.Methods：200 comatose patients caused by craniocerebral injury [（Glasgow coma scale （GCS）, 4-8] were randomly divided into two groups. All patients received routine therapy, including evacuation of intracranial hematoma, decompressive craniectomy according to operation indications, dehydration therapy to depress intracranial pressure, glucocorticoid, anti-inflammatory and supportive treatment, et al. The test group （n=100） were administrated the same treatment compare d to the other 100 patiens in the control group besides receiving meclofenoxate hydrochloride. And the clinical efficacy was evaluated by GCS. Results： In test group, the GCS were increased significantly compared with those in control group （P〈0.05）, and the result show it had no serious adverse reactions.Conclusion：Meclofenoxate hydrochloride is aneffective choice on treatment of coma caused by craniocerebral injury, and the adverse reactions are mild.

关 键 词：盐酸甲氯芬酯 颅脑损伤 昏迷 GLASGOW昏迷评分 

分 类 号：R651[医药卫生—外科学]