类风湿性关节炎辨证分型与白细胞介素6、18血清水平的关系  

Relationship between syndrome patterns of rheumatoid arthritis and interleukin-6 and interleukin-18 levels in serum

作　　者：彭玉莲[1] 任燕歌[1] 庄俊华[1] 丁海明[1] 潘婉仪[1] 邓兆智[2] 何弈婷[2] 

机构地区：[1]广东省中医院检验科,广州市510120 [2]广东省中医院风湿专科,广州市510120

出　　处：《实用医学杂志》2008年第12期2061-2063,共3页The Journal of Practical Medicine

基　　金：广东省自然科学基金资助项目(编号:04010056)

摘　　要：目的:探讨白细胞介素6(IL-6)和白细胞介素18(IL-18)血清水平与类风湿性关节炎(RA)中医辨证分型的关系。方法:采用酶联免疫吸附试验(ELISA)双抗体夹心法检测RA患者和健康人的外周血IL-6和IL-18的血清水平,分析不同证型两指标之间及其与C反应蛋白、类风湿因子含量的相关性。结果:RA患者IL-6和IL-18血清水平与健康人比较差异具有显著性,活动期RA患者IL-6水平显著高于稳定期患者(P<0.05)。风寒湿阻型患者血清IL-6浓度明显高于痰瘀互结型与肝肾两虚型(P<0.05),而与风湿热郁型无明显差异(P>0.05);而风寒湿阻型患者血清IL-18浓度明显高于风湿热郁型与肝肾两虚型(P<0.05),而与痰瘀互结型无明显差异(P>0.05)。结论:IL-6血清水平与RA的活动性密切相关,且与其中医辨证分型存在一定的联系。Objective To study the relationship between interleukin-6（IL-6） and interleukin-18（IL-18） levels in serum and the syndrome differentiation of rheumatoid arthritis（RA）. Methods The enzyme linked immunosorbent assay （ELISA） was used to measure IL-6 and IL-18 levels in serum of RA patients and healthy controls. Results The IL-6 and IL-18 levels in serum of RA patients were significantly higher than that of healthy controls（P 〈 0.05）. IL-6 level in patients with RA of cold and moist hinder type was significantly higher than that of sputum and silt hinder type and lung-kidney dual vaccity type （P 〈 0.05）, and IL-18 level in patients with RA of cold and moist hinder type was significantly higher than that of moist and heat gloomy type and lung-kidney dual vaccity type （P 〈 0.05）. Conclusions The high level of IL- 6 in serum is helpful for diagnosis of RA and estimating disease activity. There is correlation between serum level of IL-6 and the the syndrome patterns of RA.

关 键 词：关节炎 类风湿 白细胞介素-6 白细胞介素-18 

分 类 号：R259[医药卫生—中西医结合]