181例药疹患者临床分析  

Clinical analysis on 181 cases with drug eruption.

作　　者：邓丹琪[1] 王敏华[1] 张佩莲[1] 王医林[1] 刘秀红[1] 谢红[1] 周晓鸿[1] 王晓云[1] 郭芸[1] 付萍[1] 王薇[1] 靳峰阳[1] 

机构地区：[1]昆明医学院第二附属医院皮肤科,云南昆明650101

出　　处：《云南医药》2008年第3期241-244,共4页Medicine and Pharmacy of Yunnan

摘　　要：目的了解住院药疹患者的临床特点及治疗效果。方法1995～2005年间收治的181例药疹患者,对其临床资料进行回顾性分析。结果181例药疹患者中非重症药疹124例,重症药疹57例。16例符合药物超敏反应综合征(DHS)的诊断标准,占8.84%。102例由抗生素所致,40例由解热镇痛药所致,9例由别嘌呤醇所致,7例由卡马西平所致。重症药疹其住院天数、平均最高皮质类固醇用量、疗程等方面与非重症药疹相比均有显著差异。结论11年来住院药疹及重症药疹患者比例逐年增加,引起药疹的致敏药物及疹型亦有变化。别嘌呤醇和卡马西平所致重症药疹较多,应引起临床医师注意。Objective To analyze the clinical characteristics and therapeutic efficacy of inpatients with drug eruption. Methods Clinical data from 181 inpatients with drug eruption were analyzed retrospectively. Results There were 124 inpatients with non-severe type of drug eruption and 57 inpatients with severe type of drug eruption. 16 inpatients fulfilled the diagnostic criteria of drug hypersensitivity syndrome （8.84% ）.There were 102 cases with drug eruption caused by antibiotics,40 cases by antipyretic analgesic,9 cases by allopurinol,and 7 cases by carbamazepine. There were sisnificant differences in in-hospital days and course of treatment between severe type and non-severe type of drug eruption. Conclusion The proportion of inpatients with severe type of drug eruption has been increasing gradually year by year. The allergenic drug and the type of eruption are changing. Allopurinol and carbamazepine trend to provoke severe type of drug eruption.

关 键 词：药疹 临床分析 

分 类 号：R758.25[医药卫生—皮肤病学与性病学]