胺碘酮在预防心脏瓣膜置换术后房颤中的作用  

Amiodarone in the prevention of atrial fibrillation after cardiac valve replacement

作　　者：丁平[1] 李莉[1] 韩林[1] 何斌[1] 徐志云[1] 邹良健[1] 王志农[1] 

机构地区：[1]第二军医大学长海医院心胸外科,上海市200433

出　　处：《中华老年多器官疾病杂志》2008年第3期194-197,共4页Chinese Journal of Multiple Organ Diseases in the Elderly

摘　　要：目的研究胺碘酮在预防心脏瓣膜置换术后高危患者房颤中的作用。方法常规体外循环下92例窦性心律、年龄>50岁的瓣膜性心脏病择期行瓣膜置换术的患者,随机分为试验组(47例)和对照组(45例)。对照组术后给予常规药物和安慰剂。试验组除常规药物外,术后加用胺碘酮。两组比较瓣膜置换术后房颤的发生率。试验终点为术后第30天。结果瓣膜置换术后两组比较,试验组房颤发生率(8.5%)小于对照组(33.3%),有统计学意义(P<0.05)。结论胺碘酮能降低瓣膜置换术后高危患者房颤发生率,有效预防术后房颤的发生。Objective To evaluate the efficacy of amiodarone for the prevention of atrial fibrillation in high-risk patients after cardiac valve replacement. Methods Ninety-two patients over 50 years old with valvular heart disease of sinus rhythm for cardiac valve replacement were randomly divided into trial group （n=47） and control group （n= 45） . The control group was given routine medicine and placebo after the operation of cardiac valve replacement , while the trial group used routine medicine same as the control group and amiodarone in addition after the surgery. The incidences of postoperative atrial fibrillation were compared between the two groups. Thirtieth day after operation was the end point of the trial. Result The incidence of atrial fibrillation after the operation of cardiac valve replacement was significantly lower in trial group than in control group（8.5% versus 33.3%, P〈0.05）. Conclusion Amiodarone is effective in the prevention of postoperative atrial fibrillation in high-risk patients and it can decrease the incidence of atrial fibrillation after cardiac valve replacement.

关 键 词：胺碘酮 心脏瓣膜置换术 心房颤动 

分 类 号：R542.5[医药卫生—心血管疾病] R972.2[医药卫生—内科学]