盐酸埃他卡林对脑卒中易感型自发性高血压大鼠心功能的影响  

Iptakalim hydrochloride on cardiac function in stroke-prone spontaneously hypertensive rats

作　　者：朱庆磊[1] 汪海[2] 肖文彬[2] 

机构地区：[1]解放军总医院老年心血管病研究所,北京市100853 [2]军事医学科学院毒物药物研究所,北京市100850

出　　处：《中华老年多器官疾病杂志》2008年第3期208-210,214,共4页Chinese Journal of Multiple Organ Diseases in the Elderly

摘　　要：目的研究盐酸埃他卡林(Ipt)对大鼠无创心功能参数的影响。方法利用清醒无创心功能血流动力学计算机监测系统,对比研究Ipt对正常血压大鼠和脑卒中易感型自发性高血压大鼠(SHRsp)心率、心脏收缩、舒张和泵血功能的影响。结果Ipt0.5mg/kg静注可降低SHRsp心率、室缩波、抑制心肌收缩力指数,延长左室射血期和心肌电机械收缩时间,降低心输出量,延长左室舒张期。Ipt相同剂量对正常血压大鼠心功能参数却无明显影响。结论Ipt可抑制SHRsp大鼠心脏收缩和泵血功能,延长左室舒张期时间,但不影响正常血压大鼠心脏功能,提示Ipt对心功能的影响与血压状态密切相关。Objective To study the effect of iptakalim hydrochlorde （Ipt） on cardiac function in nomotensive and hypertensive rats. Methods The conscious, noninvasive cardiac function and hemodynamics method was used to comparatively determine the effect of Ipt on heart rate （HR）, cardiac systolic, diastolic and pumping functions in nomotensive rats （NTR） and stroke-prone spontaneously hypertensive rats （SHRsp）, respectively. Results HR, ventricular contractile wave, heart index and cardiac output were decreased, while total electromechanical systole time, left ventricular ejection time and left ventricular diastolic time were prolonged by Ipt 0.5 mg/kg iv in SHRsp, however, these parameters remained unchanged in NTR by the same dose of Ipt. Conclusion Ipt could suppress cardiac systolic and pumping functions, and prolong left ventricular diastolic time in SHRsp, but could not do so in NTR, which suggested that the effect of Ipt on cardiac function be related to blood pressure.

关 键 词：盐酸埃他卡林 大鼠 心脏功能试验 

分 类 号：R965.1[医药卫生—药理学] R443.5[医药卫生—药学]