乙肝疫苗免疫预防效果影响因素的巢式病例对照研究  

A nested case control study for risk factors impacting Hepatitis B Vaccination in Hebei, China

作　　者：马景臣[1] 韩彩芝[1] 齐顺祥[1] 田茶[1] 李军[1] 赵守军[2] 张勇[3] 

机构地区：[1]河北省疾病预防控制中心,石家庄050000 [2]美国加州大学旧金山分校 [3]中国疾病预防控制中心病毒病所

出　　处：《中华实验和临床病毒学杂志》2008年第3期201-204,共4页Chinese Journal of Experimental and Clinical Virology

摘　　要：目的 研究影响乙肝免疫效果的因素，探讨提高乙肝免疫预防效果的方法。方法 使用巢式病例对照研究方法，以2006年全国乙肝等疾病血清流行病调查河北现场的1734名1～15岁儿童作为研究对象，按其HBsAg是否阳性分为病例组和对照组，分析造成儿童HBsAg阳性的危险因素。结果 母亲HBsAg阳性和儿童年龄、出生医院是影响乙肝疫苗预防效果的主要因素（P〈0．0001）。结论 当前乙肝免疫预防的工作重点在于发现HBsAg阳性孕妇，同时改进农村地区的新生儿乙肝免疫预防条件。Objective Study the risk factors that impact the effectiveness of mass hepatitis B vaccination, and try to amend them in the future, Method Based on the national surveillance of hepatitis B, all the 1734 of 1-15 years old children from Hebei Province were enrolled in the present study and they were divided into case and control group according to their sera HBsAg were positive or not. Results Mother sera HBsAg positive and the hospital the children were born and earlier year of birth were risk factors. Conclusion The effectiveness of mass neonate hepatitis B vaccination has greatly improved and the future focus should be on finding pregnant HBsAg positive women, and encourage them to give birth in better hospitals, and at the mean time, try to make the neonate hepatitis B vaccination perfect, especially in country areas.

关 键 词：肝炎疫苗 乙型 危险因素 病例对照研究 接种 

分 类 号：R186[医药卫生—流行病学]